rab7b
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  • Official Full Name
  • RAB7B, member RAS oncogene family
  • Background
  • Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
  • Synonyms
  • RAB7B; RAB7B, member RAS oncogene family; ras-related protein Rab-7b; MGC9726; MGC16212; Ras related protein Rab 7b; RAB7; Ras-related protein Rab-7
Cat.#:RAB7B-193HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAB7B, MYC/DDK-tagged
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Cat.#:RAB7B-195HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAB7B, MYC/DDK-tagged
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Cat.#:RAB7B-196HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAB7B, MYC/DDK-tagged
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Cat.#:RAB7B-2133HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAB7B, GST-tagged
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Cat.#:RAB7B-2582HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAB7B 293 Cell Lysate
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Involved Pathway

RAB7B involved in several pathways and played different roles in them. We selected most pathways RAB7B participated on our site, such as Phagosome, Salmonella infection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB7B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
SFTPD; SEC22B; RAB7A; THBS2; Cd209g; VAMP3; THBS3A; ATP6V1C1B; FCGR3A; THBS4B
Salmonella infection
MAPK1; RHOGC; MAPK8; MAPK13; WASB; MAPK3; CASP1; RAC1; MAPK12B; RAB7A
Amoebiasis
GM-CSF; COL4A4; CD1d1; ACTN2; SERPINB6B; ACTN1; ADCY1; SERPINB3; SERPINB1B; IL1B2

Protein Function

RAB7B has several biochemical functions, for example, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB7B itself. We selected most functions RAB7B had, and list some proteins which have the same functions with RAB7B. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein IFT22; NOLC1; ARL4CA; SEPT8A; EEF2A.2; EEFSEC; RHOB; TUBD1; RAB42B; GUF1

Interacting Protein

RAB7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB7B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB7B.
RAP1B

RAB7B Related Articles

Day, PM; Thompson, CD; et al. Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection. JOURNAL OF VIROLOGY 87:3862-3870(2013).
Higashi, S; Moore, DJ; et al. Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 70:264-280(2011).