ric8a
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  • Official Full Name
  • resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
  • Background
  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
  • Synonyms
  • RIC8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); synembryn-A; synembryn; MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; RIC8; RIC8A_HUMAN
Cat.#:RIC8A-2842CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RIC8A
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Cat.#:RIC8A-1430ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RIC8A
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Cat.#:RIC8A-2340HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RIC8A 293 Cell Lysate
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Protein Function

RIC8A has several biochemical functions, for example, G-protein alpha-subunit binding, GTPase activator activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RIC8A itself. We selected most functions RIC8A had, and list some proteins which have the same functions with RIC8A. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein alpha-subunit binding
Related Protein RIC8B; CRHR1; ADRB2; IGF1R; RIC8A; LPAR1; HTR2A; RGS19; F2RL1; RIC8
Function GTPase activator activity
Related Protein GARNL3; LLGL1; ARAP2; GIT2B; RGS13; AXIN2; SOS1; TBC1D21; RGS5A; ARHGAP5
Function guanyl-nucleotide exchange factor activity
Related Protein RASGEF1BA; KALRN; SERGEF; ITSN1; BCAR3; CHRM4; RANGRF; FGD4; SH2D3C; FGD2
Function protein binding
Related Protein CCT5; PLEKHM1; APEX1; OSTB; ZYX; SP140; RFX6; KIF23; C1QA; PELI1

Interacting Protein

RIC8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIC8A here. Most of them are supplied by our site. Hope this information will be useful for your research of RIC8A.
UBQLN1; XPO1; TERF1; GNAI1; TUBB2A; ZNF585B; mutL; yvdC; q8xb62_eco57; UBQLN4; MAPK8IP3; pi3p; Cct4