RTEL1
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Official Full Name
regulator of telomere elongation helicase 1
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Overview
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene. -
Synonyms
RTEL1; regulator of telomere elongation helicase 1; C20orf41, chromosome 20 open reading frame 41; bK3184A7.3; DKFZP434C013; KIAA1088; NHL; RTEL; C20orf41; Chromosome 20 open reading frame 41; Novel helicase like; Regulator of telomere length; RP4-583P15.2; OTTHUMP00000031577; OTTHUMP00000184892; OTTHUMP00000221856;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- HEK293T
- Mammalian Cell
- C
- Myc
- DDK
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | RTEL1-15HCL | Recombinant Human RTEL1 Over-expression Lysate, C-Myc/DDK tagged | HEK293T | C-Myc/DDK | ||
Mouse | RTEL1-14562M | Recombinant Mouse RTEL1 Protein | Mammalian Cell | His | ||
Mouse | RTEL1-7837M | Recombinant Mouse RTEL1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | RTEL1-7837M-B | Recombinant Mouse RTEL1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | RTEL1-5191R | Recombinant Rat RTEL1 Protein | Mammalian Cell | His | ||
Rat | RTEL1-4850R | Recombinant Rat RTEL1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | RTEL1-4850R-B | Recombinant Rat RTEL1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | RTEL1-2106Z | Recombinant Zebrafish RTEL1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- RTEL1 Related Articles
RTEL1 involved in several pathways and played different roles in them. We selected most pathways RTEL1 participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with RTEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DNA Double-Strand Break Repair | CHEK2;FAM175A;KDM4A;RAD51AP1;RNF168;TDP2;TDP2B;RBBP8;PAXIP1 |
DNA Repair | ZNF830;ASCC3;MAD2L2;THRSP;INO80B;MCRS1;UBE2V2;RAD51AP1;UIMC1 |
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | RAD1;RHNO1;PPP4R2;TIMELESS;PPP4R2B;TP53BP1;PPP4CB;RBBP8;BRE |
HDR through Homologous Recombination (HRR) | RBBP8;RAD9;GEN1;EME2;RAD9B;KIAA0146;EME1;TOPBP1;RAD51AP1 |
Homology Directed Repair | TIMELESS;PPP4R2B;RTEL1;RNF4;GEN1;RHNO1;TIPIN;RAD51AP1;KIAA0146 |
Resolution of D-Loop Structures | RAD51AP1;RTEL1;GEN1;KIAA0146;EME2 |
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
RTEL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RTEL1 itself. We selected most functions RTEL1 had, and list some proteins which have the same functions with RTEL1. You can find most of the proteins on our site.
Function | Related Protein |
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4 iron, 4 sulfur cluster binding | NUBPL;ACO2;DPYD;NDUFS7;ISCA2;PPAT;NDUFS8B;RTEL1;DEM1 |
ATP binding | PFAS;PLK3;DHX9;NME4;MSH4;PRKD1;PIK3CD;RET;PRKCH |
ATP-dependent DNA helicase activity | XRCC6;BLM;CHD2;WRN;RECQL;G3BP1;BRIP1;CHD1;FBXO18 |
ATP-dependent helicase activity | CHD4A;TTF2;DHX36;CHD6;DHX37;BLM;ERCC6L2;RTEL1;SNRNP200 |
DNA binding | TCEANC2;TIGD1;MBD1;NR6A1;NR1D4A;HLTF;UNCX;STAT3;ZNF582 |
helicase activity | HELLS;SMARCA5;BAT1;MOV10;HELZ;CHD9;YTHDC2;WRN;BLM |
hydrolase activity | NUDT17;DUSP3B;DROSHA;CAPN2B;PTPN4B;ATP2A1L;GM5136;EAR1;PXYLP1 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | CHD4A;BLM;RTEL1 |
iron-sulfur cluster binding | NUBP1;REV3L;RPS3;ABAT;NFS1;CISD3;PRIM2;DPYDB;NDUFS1 |
metal ion binding | ZFP354C;LFNG;FAHD2A;ITGAE;NR1D2B;IMPDH2;MARCH6;ALOX12E;HBBE3 |
nucleic acid binding | KLF7A;SRSF7A;ZFP426;TSEN34;GLIS3;PRKRIRB;EWSR1A;TRNAU1APA;ZBTB20 |
nucleotide binding | RHOUB;PABPC5;RBM38;EFTUD1;ABCB4;RHOAA;SF3B4;FIGN;NTRK2B |
RTEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RTEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RTEL1.
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