stap1
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  • Official Full Name
  • signal transducing adaptor family member 1
  • Background
  • The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
  • Synonyms
  • STAP1; signal transducing adaptor family member 1; signal-transducing adaptor protein 1; BCR downstream signaling 1; BRDG1; STAP 1; docking protein BRDG1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein-
Cat.#:Stap1-673MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stap1 Protein, His-tagged
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Cat.#:Stap1-674RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Stap1 Protein, His-tagged
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Cat.#:STAP1-333HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human STAP1 Protein, GST-tagged
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Cat.#:STAP1-6781HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Signal Transducing Adaptor Family Member 1, His-tagged
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Cat.#:STAP1-16096MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAP1 Protein
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Cat.#:STAP1-4509RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STAP1 Protein, His-tagged
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Cat.#:STAP1-1425HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAP1 293 Cell Lysate
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Involved Pathway

STAP1 involved in several pathways and played different roles in them. We selected most pathways STAP1 participated on our site, such as B Cell Receptor Signaling Pathway, Kit Receptor Signaling Pathway, Signaling events mediated by Stem cell factor receptor (c-Kit), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
B Cell Receptor Signaling Pathway
CRK; CD79B; TTC6; NEDD9; PPP3CB; CSK; PIK3CA; AKT2; SYK; SLA2
Kit Receptor Signaling Pathway
SPRED2B; GRB7; PTPRU; SOCS4; DOK1B; PTPRUB; GRAPA; STAP1; GRAP; GRB10
Signaling events mediated by Stem cell factor receptor (c-Kit)
EVLA; STAP1; MAP4K1; SH2B3; PTPRO

Protein Function

STAP1 has several biochemical functions, for example, SH3/SH2 adaptor activity, macrophage colony-stimulating factor receptor binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAP1 itself. We selected most functions STAP1 had, and list some proteins which have the same functions with STAP1. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein STAP1; FCRL2; SH2D2A; SH2D1A; SH2D3A; SLA2; CRK; LAT; ITSN2; STAM
Function macrophage colony-stimulating factor receptor binding
Related Protein STAP1; CSF1; IL34
Function phospholipid binding
Related Protein PRKCI; APOH; SYTL4; ARHGAP44; PLEKHA3; BAD; HIP1RB; FABP1; PLA2G7; SPTBN1
Function phosphotyrosine binding
Related Protein STAP1; SAMSN1; FGR; CBL; SHC1; CBLC; PTPN3; LDLRAP1; CBLB; ACP2
Function protein binding
Related Protein CCDC116; PELO; IL1R1; GIT1; FLOT1; PDCD5; SMURF2; LOXL4; CPSF4; FOXC2
Function protein kinase binding
Related Protein AXIN1; TCTN2; USF1; EEF1A1; MAP3K13; NCS1; MAP3K12; CACNB3; EMP2; ATG13
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein STAP1; DOK2; IRS1; FRS2; GAB2; SHC1; BLNK; PIK3R1; TRAT1; SH2B2

Interacting Protein

STAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAP1.
SH3KBP1; q5jpt6_human; FAM134C; MET; AR; KIT