Recombinant Human Signal Transducing Adaptor Family Member 1, His-tagged

• Cat.No.: STAP1-6781H
• Product Overview: Recombinant humanSTAP1 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: STAP1, also known assignal-transducing adaptor protein 1, appears to functions as a dockingprotein acting downstream of Tec tyrosine kinase in B cell antigen receptorsignaling. The protein is directly phosphorylated by Tec in vitro where itparticipates in a positive feedback loop, increasing Tec activity
• Form: 20mM Tris-HCl buffer(pH8.0) containing 30% glycerol, 0.1M NaCl, 1mM DTT
• Molecular Weight: 36.8 kDa (319aa),confirmed by MALDI-TOF
• Purity: > 95% by SDS -PAGE
• Concentration: 1 mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMMAKKP PKPAPRRIFQ ERLKITALPL YFEGFLLIKR SGYREYEHYW TELRGTTLFFYTDKKSIIYV DKLDIVDLTC LTEQNSTEKN CAKFTLVLPK EEVQLKTENT ESGEEWRGFI LTVTELSVPQNVSLLPGQVI KLHEVLEREK KRRIETEQST SVEKEKEPTE DYVDVLNPMP ACFYTVSRKE ATEMLQKNPSLGNMILRPGS DSRNYSITIR QEIDIPRIKH YKVMSVGQNY TIELEKPVTL PNLFSVIDYF VKETRGNLRPFICSTDENTG QEPSMEGRSE KLKKNPHIA
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: STAP1signal transducing adaptor family member 1 [ Homo sapiens ]
• Official Symbol: STAP1
• Synonyms: STAP1; signal transducing adaptorfamily member 1; signal-transducing adaptor protein 1; BCR downstreamsignaling 1; BRDG1; STAP 1; BCR downstream signaling protein 1; BRDG1;Docking protein BRDG1; Signal transducing adaptor family member 1; Signaltransducing adaptor protein 1; STAP 1; STAP1; Stem cell adaptor protein 1;docking protein BRDG1; stem cell adaptor protein 1; BCR downstream-signalingprotein 1; signal-transducing adaptor protein-1; STAP-1
• Gene ID: 26228
• mRNA Refseq: NM_012108
• Protein Refseq: NP_036240
• MIM: 604298
• Uniprot ID: Q9ULZ2
• Chromosome Location: 4q13.2
• Pathway: B Cell Receptor Signaling Pathway,organism-specific biosystem; Kit Receptor Signaling Pathway,organism-specific biosystem; Signaling events mediated by Stem cell factorreceptor (c-Kit), organism-specific biosystem
• Function: SH3/SH2 adaptor activity