taf1
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  • Official Full Name
  • TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
  • Background
  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
  • Synonyms
  • TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S;
Cat.#:TAF1-122HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1, GST-tagged
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Cat.#:TAF1-165HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1, GST-tagged
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Cat.#:TAF1-213HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1 Protein, GST-tagged
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Cat.#:TAF1-214HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1 Protein, His-tagged
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Cat.#:TAF1-215HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1 Protein, GST-tagged
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Cat.#:TAF1-216HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1 Protein, His-tagged
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Cat.#:TAF1-222HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1 Protein, His-tagged
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Cat.#:TAF1-6954HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TAF1, GST-tagged
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Cat.#:TAF1-78HTag:His/Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1, His&FLAG-tagged
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Cat.#:TAF1-79HTag:His/Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAF1, His&FLAG-tagged
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Cat.#:TAF1-3927ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TAF1
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Cat.#:Kit-1873Tag:
Source (Host):Species:
Product nameTAF1 (BD1/BD2) Inhibitor Screening Assay Kit
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Cat.#:Kit-2032Tag:
Source (Host):Species:
Product nameTAF1 bromodomain 1 TR-FRET Assay Kit
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Cat.#:Kit-2033Tag:
Source (Host):Species:
Product nameTAF1 bromodomains 1 and 2 TR-FRET Assay Kit
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Involved Pathway

TAF1 involved in several pathways and played different roles in them. We selected most pathways TAF1 participated on our site, such as Basal transcription factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
TBPL2; GTF2F2A; GTF2F2; GTF2H2C; ERCC3; MNAT1; TAF7; TAF2; GTF2IRD1; TBPL1

Protein Function

TAF1 has several biochemical functions, for example, ATP binding, TBP-class protein binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF1 itself. We selected most functions TAF1 had, and list some proteins which have the same functions with TAF1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SPATA5L1; MYO5B; ATP2A3; DQX1; DSTYK; CDK14; ACSBG1; PAK3; RPS6KA4; ABCE1
Function TBP-class protein binding
Related Protein PSMC1; PSMC2; DR1; THRA; GTF2A2; PSMC3; BRF1; PSMC6; GTF2A1; TAF1L
Function histone acetyltransferase activity
Related Protein HTATIP; ATF2; KAT6A; KAT6B; vnc; MED24; TAF1; KAT8; HAT1; KAT2B
Function lysine-acetylated histone binding
Related Protein SMARCA4; CARM1; BRD4; BAZ1B; TAF1; BAZ2A; BRD7; BRD9; PSME4; TRIM24
Function p53 binding
Related Protein KDM1A; TP53BP1; AXIN1; SETD8; CDKN2AIP; TP73; TRIM24; RNF34; ZNF385A; TRIM29
Function protein binding
Related Protein SHANK3; ECSIT; CEBPA; JAK2; TMEM86B; TBC1D24; DRAP1; FER; PAK6; COMMD7
Function protein serine/threonine kinase activity
Related Protein SGK1; MASTL; PRPF4B; TLK2; PRKCQ; PRKCHA; NEK1; STK16; RIOK3; SIK2
Function sequence-specific DNA binding
Related Protein HLX; ZNF498; ZKSCAN3; DLX2B; FOXN4; TAF1; POU2F1B; RORB; HOXA4; HOXA4A
Function transcription coactivator activity
Related Protein RXRB; HIF3A; YAF2; NCOA2; TADA2B; ENY2; LPIN1; ESRRB; KMT2E; SRA1
Function transcription factor binding
Related Protein HMGB1; RBL1; HDAC1; PIK3R1; KAT8; TLE1; GNPTAB; HIF1A; PSMD4; PIAS1
Function contributes_to transcription regulatory region DNA binding
Related Protein TCF3; TCF12; ATF4; HAND1; NFYA; NR1H3; NFYB; NFYC; TAF1; HDAC4

Interacting Protein

TAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF1.
TBP; e1a_ade05; GTF2F1; E2; E2; rpl31_human_gene; rl34_human_gene; rps10_human_gene; RB1; DYSF; DNAJB5

TAF1 Related Articles

Sako, W; Morigaki, R; et al. IDENTIFICATION AND LOCALIZATION OF A NEURON-SPECIFIC ISOFORM OF TAF1 IN RAT BRAIN: IMPLICATIONS FOR NEUROPATHOLOGY OF DYT3 DYSTONIA. NEUROSCIENCE 189:100-107(2011).
Bergstralh, DT; Conti, BJ; et al. Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. EXPERIMENTAL CELL RESEARCH 313:65-76(2007).
Tseng, L; Tang, MY; et al. Progesterone receptor (hPR) upregulates the fibronectin promoter activity in human decidual fibroblasts. DNA AND CELL BIOLOGY 22:633-640(2003).