tcn2
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  • Official Full Name
  • transcobalamin II
  • Background
  • This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred;to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the;transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin;I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing;results in multiple transcript variants.
  • Synonyms
  • TCN2; transcobalamin II; macrocytic anemia; transcobalamin-2; D22S676; D22S750; TC2; II; OTTHUMP00000199117; OTTHUMP00000199118; OTTHUMP00000199119; TC; TC II; TC-2; TCII; TCO2_HUMAN; Transcobalamin 2; Vitamin B12 binding protein 2; vitamin B12-binding protein 2
Cat.#:TCN2-570HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCN2 Protein, His-tagged
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Cat.#:Tcn2-571RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tcn2 Protein, His-tagged
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Cat.#:TCN2-429HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TCN2, His tagged
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Cat.#:TCN2-873HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TCN2, His tagged
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Cat.#:Tcn2-4074MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tcn2, His tagged
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Cat.#:TCN2-5991RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TCN2 Protein
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Cat.#:TCN2-6639ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TCN2
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Cat.#:TCN2-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TCN2 cell lysate
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Cat.#:TCN2-2772HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TCN2 cell lysate
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Cat.#:TCN2-1857MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TCN2 cell lysate
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Involved Pathway

TCN2 involved in several pathways and played different roles in them. We selected most pathways TCN2 participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vitamin digestion and absorption
APOA4; CUBN; SLC52A3; MMACHC; FOLH1; BTD; SLC23A1; PNLIP; LMBRD1; SLC19A2

Protein Function

TCN2 has several biochemical functions, for example, cobalamin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCN2 itself. We selected most functions TCN2 had, and list some proteins which have the same functions with TCN2. You can find most of the proteins on our site.
Function
Related Protein
Function cobalamin binding
Related Protein TCN1; TCN2; CUBN; LMBRD1; MMACHC; MUT; TCNL; GIF; CD320
Function metal ion binding
Related Protein CLCA3; ATP2B3A; BCL11B; STK25; CYP2A12; UBA5; THRAA; SPNA1; YDJC; KLK1B4

Interacting Protein

TCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCN2.
PAXIP1; q7cgj6_yerpe