tph1
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  • Official Full Name
  • tryptophan hydroxylase 1
  • Background
  • This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
  • Synonyms
  • TPH1; tryptophan hydroxylase 1; TPRH; TRPH; tryptophan 5-hydroxylase 1; L-tryptophan hydroxylase; tryptophan 5-monooxygenase 1; indoleacetic acid-5-hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase);
Cat.#:TPH1-1723MTag:His-SUMO
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse TPH1 protein, His-SUMO-tagged
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Cat.#:TPH1-1172HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPH1, His tagged
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Cat.#:TPH1-3367HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPH1, His-tagged
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Cat.#:TPH1-17252MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TPH1 Protein
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Cat.#:TPH1-6239RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TPH1 Protein
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Cat.#:TPH1-6515CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TPH1
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Cat.#:TPH1-847HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TPH1 293 Cell Lysate
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Involved Pathway

TPH1 involved in several pathways and played different roles in them. We selected most pathways TPH1 participated on our site, such as Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tryptophan metabolism
TDO2B; ANI_1_2390104; GCDHB; GCDHA; AADAT; ALDH2.2; HAAO; OGDHL; HADHAA; HADHAB
Metabolic pathways
PRPS2; HYAL3; PIGL; PRODH2; ST3GAL4; R05D11.9; ACSL5; GALNT1; GALNT12; DSE
Serotonergic synapse
GNAS; KCNN2; RAF1; GABRB3; HTR4; CYP2D26; GNG12; GNAO1; CYP4X1; PTGS2

Protein Function

TPH1 has several biochemical functions, for example, amino acid binding, iron ion binding, tryptophan 5-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPH1 itself. We selected most functions TPH1 had, and list some proteins which have the same functions with TPH1. You can find most of the proteins on our site.
Function
Related Protein
Function amino acid binding
Related Protein TH; GCHFR; AARS; TDO2; AARS2; KARS; DDC; SHMT2; ASS1; GOT2
Function iron ion binding
Related Protein CYP2C8; PLOD3; ALOX5B.2; PDF; CYP7A1; Scd1; TYW1B; CYP19A1B; HBBE3; CYP4V8
Function tryptophan 5-monooxygenase activity
Related Protein TH2; TPH1B; TPH2; TPH1; TPH1A

Interacting Protein

TPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPH1.
MYC

TPH1 Related Articles

Oberkofler, CE; Limani, P; et al. Systemic Protection Through Remote Ischemic Preconditioning Is Spread by Platelet-Dependent Signaling in Mice. HEPATOLOGY 60:1409-1417(2014).
Patrick, RP; Ames, BN; et al. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB JOURNAL 28:2398-2413(2014).