ACAA1
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Official Full Name
acetyl-CoA acyltransferase 1
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Overview
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. -
Synonyms
ACAA1; acetyl-CoA acyltransferase 1; acetyl Coenzyme A acyltransferase 1; 3-ketoacyl-CoA thiolase, peroxisomal; peroxisomal 3 oxoacyl Coenzyme A thiolase; beta-ketothiolase; peroxisomal 3-oxoacyl-CoA thiolase; acetyl-Coenzyme A acyltransferase 1; peroxiso;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ACAA1 involved in several pathways and played different roles in them. We selected most pathways ACAA1 participated on our site, such as Fatty acid degradation, Valine, leucine and isoleucine degradation, alpha-Linolenic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid degradation | CPT2;CYP4A11;ADH1A;ACSBG2;ALDH7A1;ALDH2.2;ADH2-1;ACSL1A;ACAA2 |
| Valine, leucine and isoleucine degradation | HMGCL;ACAT2;HIBADHB;HMGCLL1;ALDH9A1;BCAT1;HIBADH;OXCT1A;AOX2P |
| alpha-Linolenic acid metabolism | PLA2G12A;PLA2G4AA;ACOX1;FADS2;PLA2G2E;PLA2G4C;PLA2G2F;PLA2G2D;PLA2G5 |
| Biosynthesis of unsaturated fatty acids | PTPLA;BAAT;TECR;Scd1;ACOX3;HADHAA;ACAA1A;ELOVL2;ACOT1 |
| Metabolic pathways | CHDH;ACSL1B;NOS2;NME7;LIPT1;ADPGK;ENOPH1;SRM;ENO1B |
| Fatty acid metabolism | ACSL1A;ELOVL5;CPT1B;ACACA;PTPLAD1;ACADVL;ACAA1A;ELOVL6;ACSL4B |
| PPAR signaling pathway | Scd2;MMP1A;DBI;HMGCS2;GK2;PDPK1;FABP4;ACSL3B;FABP3 |
| Peroxisome | MVK;GSTK1;HSD17B4;HMGCLL1;DAO.2;CROT;PEX1;MPV17L2;DDO |
ACAA1 has several biochemical functions, for example, acetyl-CoA C-acyltransferase activity, palmitoyl-CoA oxidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAA1 itself. We selected most functions ACAA1 had, and list some proteins which have the same functions with ACAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetyl-CoA C-acyltransferase activity | ACAA2;HADHB;ACAA1;ACAA1A |
| palmitoyl-CoA oxidase activity | ACAA1;ACAA1A;ACOX1;ACADL;ACOXL |
| protein binding | SRP14;DSTN;C20orf20;XBP1;PPARA;CD8B1;NCKAP1;LRRC33;PPP1R3C |
ACAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAA1.
TXNDC11; ere_dna
- Q&As
- Reviews
Q&As (10)
Ask a questionModulating its activity could potentially treat metabolic disorders or enhance ketone body production.
It is a dimeric protein with a helix-turn-helix motif.
It plays a crucial role in beta-oxidation of fatty acids and ketone body synthesis.
It catalyzes the transfer of an acyl group from acyl-CoA to CoA.
It interacts with other enzymes in the beta-oxidation pathway, including acyl-CoA dehydrogenases and enoyl-CoA hydratases.
Its expression is regulated by transcription factors, hormones, and metabolic signals.
It is involved in the metabolism of long-chain fatty acids, branched-chain amino acids, and isoprenoids.
Deficiency can lead to metabolic disorders, such as hypoketotic hypoglycemia, while overexpression may increase ketone body production.
It is expressed in various tissues, including liver, adipose tissue, and muscle.
Dysregulation of its activity may contribute to the development of metabolic diseases such as diabetes and obesity.
Customer Reviews (2)
Write a reviewProvides high signal-to-noise ratio and low background in detection of the target protein in various assays.
Highly effective in blocking the activity of the target protein in functional studies.
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