AGXT2
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Official Full Name
alanine--glyoxylate aminotransferase 2
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Overview
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. -
Synonyms
AGXT2; alanine--glyoxylate aminotransferase 2; alanine glyoxylate aminotransferase 2; alanine--glyoxylate aminotransferase 2, mitochondrial; AGT2; beta ALAAT II; beta alanine pyruvate aminotransferase; beta-ALAAT II; beta-alanine-pyruvate aminotransferase;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc|DDK
- N
- Involved Pathway
- Protein Function
- Interacting Protein
AGXT2 involved in several pathways and played different roles in them. We selected most pathways AGXT2 participated on our site, such as Alanine, aspartate and glutamate metabolism, Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGXT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alanine, aspartate and glutamate metabolism | GLUL;NIT2;ASNS;FOLH1;AGXTA;DDO;ybaS;ABAT;ALDH5A1 |
Glycine, serine and threonine metabolism | SHMT2;PGAM1;CBSB;GCSHB;AGXTA;DAO;CBSA;AGXT2;MAOB |
Cysteine and methionine metabolism | CTH;GCLM;SDS;GSS;CBSA;AMD1;AHCYL1;CDO1;DNMT3A |
Metabolic pathways | GLYCTK;PDHA1;NME1;DGKZ;DNMT4;NANSA;AKR1A1A;LCT;PLCD1 |
AGXT2 has several biochemical functions, for example, alanine-glyoxylate transaminase activity, catalytic activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGXT2 itself. We selected most functions AGXT2 had, and list some proteins which have the same functions with AGXT2. You can find most of the proteins on our site.
Function | Related Protein |
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alanine-glyoxylate transaminase activity | AGXT2;AGXT;AGXTB;AGXTA |
catalytic activity | SLC27A1B;GTF2F2B;GOT1L1;PCYT1BA;HPGD;GNSB;PHKB;SYN1;THA1 |
identical protein binding | S100A2;SOX10;ATXN3;PLDN;SERPINA1;BIRC5;NFKBIA;C;GRB7 |
pyridoxal phosphate binding | CCBL1;MOCOS;Alb;GOT2;CSAD;CCBL2;AGXT;ETNPPL;AGXT2 |
transaminase activity | AGXTB;AGXT2;AGXTA;AMT;AGXT2L1;GOT1L1;CCBL1;AGXT;PHYKPL |
AGXT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGXT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGXT2.
- Q&As
- Reviews
Q&As (10)
Ask a questionAGXT2 activity may be affected by oxidative stress due to the potential modification of critical cysteine residues in the enzyme's active site. Such modifications might impact its ability to detoxify glyoxylate effectively.
Yes, mutations in the AGXT2 gene have been linked to primary hyperoxaluria type 3 (PH3), a rare genetic disorder characterized by excessive oxalate production, leading to kidney stone formation and renal failure.
AGXT2 may interact with specific signaling pathways related to oxidative stress, inflammation, and calcium homeostasis, which could contribute to kidney stone formation and renal health.
AGXT2 and AGXT share similarities in their enzymatic functions, but AGXT is primarily expressed in the liver and catalyzes the conversion of glyoxylate and alanine to glycine, while AGXT2 is expressed in various tissues and has a broader substrate specificity.
AGXT2 has potential as a therapeutic target for managing oxalate-related diseases, such as PH3. Modulating AGXT2 activity might help reduce oxalate levels and prevent kidney stone formation.
Identification of AGXT2-related biomarkers could aid in early detection and diagnosis of metabolic disorders, especially those involving oxalate metabolism and kidney stone disease.
AGXT2 expression is regulated by various factors, including nuclear receptors and transcription factors. Post-translational modifications, such as phosphorylation and acetylation, can also modulate its enzymatic activity.
AGXT2 is primarily expressed in the liver, kidneys, and the central nervous system, where it localizes to mitochondria.
AGXT2 is involved in the detoxification of glyoxylate, preventing its accumulation, which is crucial in avoiding calcium oxalate kidney stone formation and various metabolic disorders.
AGXT2 requires pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, as a cofactor for its enzymatic activity. PLP assists in the transfer of amino groups during the transamination reactions.
Customer Reviews (5)
Write a reviewThe post-sale services provided detailed technical support and ensured that I had a positive experience with their products.
I was pleasantly surprised by how user-friendly this protein is – a must-have!
The pricing structure for their proteins is transparent and reasonable.
The quality and performance of this recombination protein are matched.
This protein is so versatile, it suits a wide range of applications.
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