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Recombinant Human AGXT2 Protein, His-tagged

Cat.No. : AGXT2-156H
Product Overview : Recombinant Human AGXT2 fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His
Form : 50mM Tris, 8M Urea, pH8.0.
Molecular Mass : 52.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : AGXT2 alanine--glyoxylate aminotransferase 2 [ Homo sapiens ]
Official Symbol : AGXT2
Synonyms : AGXT2; alanine--glyoxylate aminotransferase 2; alanine glyoxylate aminotransferase 2; alanine--glyoxylate aminotransferase 2, mitochondrial; AGT2; beta ALAAT II; beta alanine pyruvate aminotransferase; beta-ALAAT II; beta-alanine-pyruvate aminotransferase; (R)-3-amino-2-methylpropionate--pyruvate transaminase; DAIBAT;
Gene ID : 64902
mRNA Refseq : NM_031900
Protein Refseq : NP_114106
MIM : 612471
UniProt ID : Q9BYV1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is AGXT2 activity altered under conditions of oxidative stress? 05/26/2022

AGXT2 activity may be affected by oxidative stress due to the potential modification of critical cysteine residues in the enzyme's active site. Such modifications might impact its ability to detoxify glyoxylate effectively.

Are there any known genetic variants or mutations of AGXT2 associated with metabolic diseases? 04/23/2022

Yes, mutations in the AGXT2 gene have been linked to primary hyperoxaluria type 3 (PH3), a rare genetic disorder characterized by excessive oxalate production, leading to kidney stone formation and renal failure.

Are there any AGXT2-related signaling pathways involved in kidney stone formation and renal health? 11/03/2021

AGXT2 may interact with specific signaling pathways related to oxidative stress, inflammation, and calcium homeostasis, which could contribute to kidney stone formation and renal health.

How does AGXT2 differ from AGXT, the enzyme associated with primary hyperoxaluria type 1 (PH1)? 10/15/2021

AGXT2 and AGXT share similarities in their enzymatic functions, but AGXT is primarily expressed in the liver and catalyzes the conversion of glyoxylate and alanine to glycine, while AGXT2 is expressed in various tissues and has a broader substrate specificity.

Can AGXT2 serve as a therapeutic target for managing oxalate-related diseases? 08/06/2020

AGXT2 has potential as a therapeutic target for managing oxalate-related diseases, such as PH3. Modulating AGXT2 activity might help reduce oxalate levels and prevent kidney stone formation.

Are there any potential AGXT2 biomarkers for the early diagnosis of metabolic diseases? 01/30/2020

Identification of AGXT2-related biomarkers could aid in early detection and diagnosis of metabolic disorders, especially those involving oxalate metabolism and kidney stone disease.

How is AGXT2 activity regulated at the transcriptional and post-translational levels? 04/05/2019

AGXT2 expression is regulated by various factors, including nuclear receptors and transcription factors. Post-translational modifications, such as phosphorylation and acetylation, can also modulate its enzymatic activity.

What are the tissue distribution and cellular localization of AGXT2 in the human body? 03/11/2019

AGXT2 is primarily expressed in the liver, kidneys, and the central nervous system, where it localizes to mitochondria.

What role does AGXT2 play in the metabolism of glyoxylate and its implications for human health? 07/31/2018

AGXT2 is involved in the detoxification of glyoxylate, preventing its accumulation, which is crucial in avoiding calcium oxalate kidney stone formation and various metabolic disorders.

What is the relationship between AGXT2 and vitamin B6 (pyridoxine) in the context of enzymatic activity? 03/20/2018

AGXT2 requires pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, as a cofactor for its enzymatic activity. PLP assists in the transfer of amino groups during the transamination reactions.

Customer Reviews (5)

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Reviews
04/05/2021

    The post-sale services provided detailed technical support and ensured that I had a positive experience with their products.

    12/16/2020

      I was pleasantly surprised by how user-friendly this protein is – a must-have!

      07/14/2019

        The pricing structure for their proteins is transparent and reasonable.

        05/09/2019

          The quality and performance of this recombination protein are matched.

          09/30/2018

            This protein is so versatile, it suits a wide range of applications.

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