AHNAK
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Official Full Name
AHNAK nucleoprotein
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Overview
Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene. AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque. AHNAK has been shown to be essential for pseudopod protrusion and cell migration. -
Synonyms
AHNAK; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); neuroblast differentiation-associated protein AHNAK; desmoyokin; AHNAK-related; MGC5395; PM227; AHNAKRS; OTTHUMP00000236155; OTTHUMP00000236448; OTTHUMP00000236450; OTTHUMP00000236451; Desmoyokin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- His
- Involved Pathway
- Protein Function
- Interacting Protein
- AHNAK Related Articles
AHNAK involved in several pathways and played different roles in them. We selected most pathways AHNAK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHNAK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
AHNAK has several biochemical functions, for example, S100 protein binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHNAK itself. We selected most functions AHNAK had, and list some proteins which have the same functions with AHNAK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S100 protein binding | ATP2A2;S100A11;ANXA2;DDX1;ANXA11;FGF1A;KCNK3;AGER;S100A6 |
| poly(A) RNA binding | EIF4B;RBM8A;MRPL39;SFPQ;NCBP1;MRM1;RPL36A;MRPL21;MEX3B |
| protein binding | CISH;XK;GZMB;DGKZ;EXOSC8;ALPL;RWDD3;STX2;PLCB1 |
| structural molecule activity conferring elasticity | TTN;AHNAK |
AHNAK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHNAK here. Most of them are supplied by our site. Hope this information will be useful for your research of AHNAK.
EGFR; Anxa2; S100A10; YWHAZ; Tpr; Bles03; Csnk1e; p27958-pro_0000037576; fopA1; acnA; q7cfv5_yerpe; pz-A; POT1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; midostaurin
- Q&As
- Reviews
Q&As (10)
Ask a questionAHNAK has been linked to mechanosensitive signaling pathways, and its interaction with proteins involved in the cytoskeleton and membrane repair suggests a role in cellular responses to mechanical stress and stretch.
AHNAK contains several functional domains, including the AHNAK repeat domain (ARD), the ankyrin repeat domain (ANK), and the spectrin repeat domain (SRD).
AHNAK has been shown to interact with proteins involved in lipid metabolism and lipid droplet formation, suggesting a role in lipid droplet dynamics and lipid homeostasis within cells.
AHNAK interacts with actin and microtubule networks, influencing cytoskeletal dynamics and cell motility.
Yes, AHNAK can also undergo acetylation, glycosylation, and ubiquitination, which can modulate its function and stability.
AHNAK has been implicated in cancer metastasis, invasion, and cell migration, suggesting its potential role as a metastasis-associated protein in certain cancers.
Yes, AHNAK interacts with voltage-gated potassium channels (Kv1.5), regulating their localization at the plasma membrane and potentially affecting their activity.
AHNAK is recruited to the site of membrane damage, where it interacts with annexins and facilitates membrane resealing, contributing to membrane repair.
AHNAK binds to and modulates the activity of proteins involved in calcium signaling pathways, such as annexins and the plasma membrane calcium ATPase (PMCA).
AHNAK interacts with various adhesion proteins and the cytoskeleton, playing a role in stabilizing cell-cell and cell-matrix interactions and modulating cell migration.
Customer Reviews (5)
Write a reviewThe efficacy and dependability of this lab protein underscore its role as a pivotal component in our laboratory's scientific pursuits.
This protein rocks! It's made our experiments so much easier.
Prefect results demonstartion. Love it!
Seriously impressed with the results from this lab protein.
We confidently endorse this lab protein for its ability to produce dependable and replicable data, aligning with rigorous scientific standards.
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