alkbh3
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  • Official Full Name
  • alkB, alkylation repair homolog 3 (E. coli)
  • Background
  • The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA;lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the;removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)).
  • Synonyms
  • ALKBH3; alkB, alkylation repair homolog 3 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3; ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793
Cat.#:ALKBH3-2538HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALKBH3 Protein, GST-tagged
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Cat.#:ALKBH3-2544HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALKBH3 Protein, MYC/DDK-tagged
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Cat.#:ALKBH3-26501THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALKBH3, His-tagged
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Cat.#:ALKBH3-970HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3, His-tagged
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Cat.#:ALKBH3-9584HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALKBH3, GST-tagged
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Cat.#:ALKBH3-1555MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALKBH3 Protein
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Cat.#:ALKBH3-631RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALKBH3 Protein
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Cat.#:ALKBH3-306RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ALKBH3 Protein, His-tagged
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Cat.#:ALKBH3-5459CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALKBH3
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Cat.#:ALKBH3-952ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALKBH3
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Cat.#:ALKBH3-8901HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ALKBH3 293 Cell Lysate
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Involved Pathway

ALKBH3 involved in several pathways and played different roles in them. We selected most pathways ALKBH3 participated on our site, such as ALKBH3 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ALKBH3 mediated reversal of alkylation damage
ASCC1; ASCC3; ALKBH3; ASCC2
DNA Damage Reversal
ASCC2; ASCC3; ASCC1; MGMT; ALKBH2; ALKBH3
DNA Repair
BABAM1; SMARCA5; UIMC1; DNA2; ASCC2; ZNF830; TIPIN; TDP1; POLD3; PPP4CB
Reversal of alkylation damage by DNA dioxygenases
ALKBH2; ASCC3; ASCC2; ASCC1; ALKBH3

Protein Function

ALKBH3 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity, L-ascorbic acid binding, cytosine C-5 DNA demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH3 itself. We selected most functions ALKBH3 had, and list some proteins which have the same functions with ALKBH3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA-N1-methyladenine dioxygenase activity
Related Protein KDM5BB; FTO; PHF2; ALKBH3; KDM5D; ALKBH2; JMJD1C
Function L-ascorbic acid binding
Related Protein P4HA1A; DBH; FAM125B; P4HA1; TMLHE; LEPRE1; PHYH; EGLN2; PLOD3; OGFOD1
Function cytosine C-5 DNA demethylase activity
Related Protein ALKBH2; ALKBH3
Function ferrous iron binding
Related Protein ALKBH1; PLOD1; DNAJC24; FECH; SNCA; TET2; HAAO; NT5E; BCO1; TF
Function protein binding
Related Protein COQ9; KRT8; ADAMTS10; PDLIM3; EGLN1; KRT14; CSE1L; STMN2; APOL1; STK3

Interacting Protein

ALKBH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH3.
GLRX3; GOLGA2; IKZF1; LNX1; AK8; SRPK2; SRPK1

ALKBH3 Related Articles

Vagbo, CB; Svaasand, EK; et al. Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA REPAIR 12:188-195(2013).
Meza, TJ; Moen, MN; et al. The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. NUCLEIC ACIDS RESEARCH 40:6620-6631(2012).