acat1
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  • Official Full Name
  • acetyl-CoA acetyltransferase 1
  • Background
  • This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
  • Synonyms
  • ACAT1; acetyl-CoA acetyltransferase 1; ACAT, acetyl Coenzyme A acetyltransferase 1; acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl Coenzyme A thiolase; THIL; acetoacetyl-CoA thiolase; acetyl-Coenzyme A acetyltransferase 1; mitochondrial acetoac
Cat.#:ACAT1-141HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACAT1 Protein, GST-Tagged
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Cat.#:ACAT1-142HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACAT1 Protein, GST-Tagged
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Cat.#:ACAT1-3045HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACAT1, His-tagged
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Cat.#:ACAT1-361HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human acetyl-CoA acetyltransferase 1, His-tagged
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Cat.#:Acat1-8159MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acat1 protein, His & T7-tagged
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Cat.#:Acat1-3050RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Acat1, His-tagged
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Cat.#:ACAT1-265CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACAT1 Protein, His-tagged
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Cat.#:ACAT1-201RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACAT1 Protein, His-tagged
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Cat.#:ACAT1-5141CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACAT1
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Cat.#:ACAT1-1085ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACAT1
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Involved Pathway

ACAT1 involved in several pathways and played different roles in them. We selected most pathways ACAT1 participated on our site, such as Fatty acid degradation, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid degradation
ACSL3A; ACADL; ACSBG2; ADH1B; ADH1; ACSL1; ACSL1B; CPT1B; CYP4A14; ALDH1B1
Synthesis and degradation of ketone bodies
OXCT1B; BDH1; BDH2; OXCT2; OXCT1; OXCT2A; OXCT1A; ACAT2; OXCT2B; HMGCLL1
Valine, leucine and isoleucine degradation
ACAT2; MUT; ALDH9A1; PCCA; MCCC2; ACAT1; ACADS; BCKDHB; ALDH6A1; BCKDHA
Lysine degradation
OGDH; BBOX1; ASH1L; SETD1B; AGPHD1; HADHAB; ACAT2; AADAT; SUV39H1A; GLT25D2
Tryptophan metabolism
TPH1B; ALDH7A1; IL4I1; OGDHA; GCDHA; HADHAA; AOX2P; AADAT; ACAT1; CYP1A
Pyruvate metabolism
SLC16A1; PDK2; ackA; PKMA; PDP1; PDPR; PKLR; hchA; PCK1; ALDH2.2
Glyoxylate and dicarboxylate metabolism
MDH1AA; HYI; AFMID; GRHPR; AMT; ACO2; PCCA; CS; DHDPSL; PCCB
Propanoate metabolism
MUT; LDHB; BCKDHB; PCCA; ackA; ALDH6A1; ACSS2; PCCB; HADHAB; MLYCD
Butanoate metabolism
ACAT2; OXCT1; ECHS1; HADHA; OXCT2B; OXCT1A; EHHADH; GAD1; ACSM5; ACSM2
Terpenoid backbone biosynthesis
FDPS; NUS1; ZMPSTE24; HMGCS1; HMGCS2; DHDDS; ICMT; PDSS1; FNTB; ACAT1
Metabolic pathways
GBGT1; ALDH9A1; PPAP2D; MTMR7B; B4GALT7; ACLY; NMNAT1; NAPRT1; GALT; GNPDA2
Carbon metabolism
AGXTA; ENO2; PRPS1; FH1; PRPS1A; GPI1; PCCB; SDS; GLDC; ME3
Fatty acid metabolism
ACSL1A; ACSL4B; ACAA2; HADHAB; ACADL; ACSBG1; ACADVL; HADHB; ACSL5; PTPLAD1

Protein Function

ACAT1 has several biochemical functions, for example, acetyl-CoA C-acetyltransferase activity, coenzyme binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAT1 itself. We selected most functions ACAT1 had, and list some proteins which have the same functions with ACAT1. You can find most of the proteins on our site.
Function
Related Protein
Function acetyl-CoA C-acetyltransferase activity
Related Protein ACAT2; ACAA1A; ACAT1; HADHA
Function coenzyme binding
Related Protein NDUFA9; TSTA3; ATAT1; WWOX; TDH; HMGCRA; GCH1; NDUFA9A; HMGCR; QDPRB1
Function enzyme binding
Related Protein LAMP2; DIS3L; LDB1; ZFP36; UGT1A1; KPNB1; CFTR; CNTNAP2; CAV1; RPS2
Function metal ion binding
Related Protein GFI1AA; ADCY9; PHC2A; TRAFD1; ZNF136; ZNF185; ITPA; NME3; ZNF436; NR1D4B
Function protein homodimerization activity
Related Protein HEYL; AMBP; TDG; SRGAP2; LILRB1; BCL2; SYT16; CAMK2B; IMPA2; HMGCS1

Interacting Protein

ACAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAT1.
VCAM1; EIF1B; GH1; MCC; MPG; HLA-B; HLA-C; TNIK; AGXT; GABARAPL2; SIRT4

ACAT1 Related Articles

Chang, HT; Olson, LK; et al. Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy. NUTRITION & METABOLISM 10:-(2013).
Yang, Y; Wang, YF; et al. Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL. JOURNAL OF LIPID RESEARCH 54:34-43(2013).