ADAT3
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Official Full Name
adenosine deaminase, tRNA-specific 3
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Synonyms
ADAT3; adenosine deaminase, tRNA-specific 3; adenosine deaminase, tRNA specific 3, TAD3 homolog (S. cerevisiae); tRNA-specific adenosine deaminase-like protein 3; TAD3; tRNA specific adenosine deaminase 3 homolog (S. cerevisiae); S863 5; FWP005; LOC113179; MST121; MSTP121; tRNA specific adenosine 34 deaminase subunit ADAT3; tRNA specific adenosine deaminase like protein 3; tRNA-specific adenosine deaminase 3 homolog; adenosine deaminase, tRNA-specific 3, TAD3 homolog; tRNA-specific adenosine-34 deaminase subunit ADAT3; S863-5;
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADAT3 Related Articles
ADAT3 involved in several pathways and played different roles in them. We selected most pathways ADAT3 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Gene Expression | CTGF;ZNF264;SKI;PAPOLA;ZNF559;POLRMT;ZNF680;RXRBB;PTBP1 |
tRNA modification in the nucleus and cytosol | LCMT2;TRMT44;TRMT61A;OSGEP;THG1L;ADAT2;TRMT112;PUS1;CCDC76 |
tRNA processing | TP53RK;POP4;RPP38;KIAA1456;PUS1;MANEA;TYW3;FAM98B;TRMT112 |
ADAT3 has several biochemical functions, for example, contributes_to deaminase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAT3 itself. We selected most functions ADAT3 had, and list some proteins which have the same functions with ADAT3. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to deaminase activity | RPUSD2;RPUSD3;RPUSD4;ADAT3;RPUSD1 |
zinc ion binding | APOBEC3B;GATA4;ZDHHC19;RNF26;LMO2;MKRN2;TRPS1;DRL;PCGF5B |
ADAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAT3.
THRB
- Q&As
- Reviews
Q&As (13)
Ask a questionTo the best of our knowledge, there are currently no drugs that specifically target ADAT3 in clinical development. However, there may be drugs that indirectly affect ADAT3 function or expression, and further research may identify potential drug targets within the ADAT3 pathway.
ADAT3 protein is not currently used in diagnostic testing, although it is an active area of research. However, ADAT3 expression levels have been shown to correlate with prognosis and tumor progression in certain types of cancer, suggesting that it may have diagnostic value in the future.
There is some evidence to suggest that ADAT3 may play a role in regulating the immune response, although the extent of its involvement is still not fully understood. ADAT3 has been shown to regulate the expression of genes involved in cytokine signaling, which is essential for coordinating the immune response to infections and other invaders. Further research is needed to fully understand the role of ADAT3 in the immune system.
There are currently no FDA-approved drugs that target ADAT3 specifically. However, some existing drugs may indirectly affect ADAT3 function or expression. For example, FDA-approved cancer drugs such as gemcitabine have been shown to inhibit the expression of ADAT3 in cancer cells.
While ADAT3 is expressed in many different tissues and cell types, its expression is not ubiquitous and can vary depending on the specific context. For example, ADAT3 is expressed at higher levels in certain types of cancers and immune cells, suggesting that it may play a more prominent role in these contexts.
While ADAT3 has not been directly implicated in any specific neurodegenerative diseases, its role in regulating the expression of genes involved in nervous system function and development suggests that it could potentially play a role in these diseases. Further research is needed to fully understand the extent of ADAT3's involvement in neurodegenerative diseases.
While ADAT3 itself is not typically used in gene therapy, its role in RNA editing makes it a potentially useful target for gene therapy. By editing RNA transcripts to alter the amino acid sequence of proteins, ADAT3 could be used to correct genetic mutations that cause or contribute to disease.
It is possible that ADAT3 could be used as a drug target for other diseases besides cancer, particularly those involving dysregulated RNA editing. However, more research is needed to understand the full range of ADAT3's roles and interactions within cells and tissues before it can be considered a viable drug target for other diseases.
There is some evidence suggesting that ADAT3 may play a role in drug resistance in certain types of cancer cells. Specifically, ADAT3 has been shown to regulate the expression of genes involved in drug efflux, which can contribute to resistance to chemotherapy. Further research is needed to fully understand the extent of ADAT3's involvement in drug resistance.
The potential therapeutic applications of ADAT3 protein include targeted cancer therapy, where inhibition of ADAT3 has been shown to inhibit tumor growth in preclinical models. Additionally, modulating the function of ADAT3 could have therapeutic benefits in other diseases where RNA editing is dysregulated, such as neurological disorders.
ADAT3 protein can be produced using recombinant DNA technology, which involves cloning and expressing the ADAT3 gene in a host cell such as bacteria or yeast. The protein can then be purified and used for research or therapeutic purposes.
Yes, ADAT3 has been identified as a potential target for cancer therapy due to its role in promoting cancer cell growth and survival. Inhibition of ADAT3 activity could be a strategy for developing new cancer treatments.
Currently, there are no diagnostic tests that directly measure ADAT3 protein levels or activity. However, research is ongoing to investigate the potential use of ADAT3 as a biomarker for certain types of cancer.
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