AP2S1
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Official Full Name
adaptor-related protein complex 2, sigma 1 subunit
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Overview
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts. -
Synonyms
AP2S1; adaptor-related protein complex 2, sigma 1 subunit; CLAPS2; AP-2 complex subunit sigma; Adapter-related protein complex 2 sigma subunit; Adaptor protein complex AP2 subunit sigma; Adaptor related protein complex 2 sigma 1 subunit; AI043088; AP 17; AP 2 complex subunit sigma 1; AP17; AP17 delta; AP2 complex subunit sigma 1; CLAPS 2; Clathrin adaptor complex AP2, sigma subunit; Clathrin adaptor protein AP17; Clathrin assembly protein 2 small chain; Clathrin associated/assembly/adaptor protein small 2; Clathrin associated/assembly/adaptor protein small 2, 17-KD; Clathrin coat assembly protein AP17; Clathrin coat associated protein AP17; HA2 17 kDa subunit; MGC62945; Plasma membrane adaptor AP 2 17 kDa protein; Plasma membrane adaptor AP-2 17 kDa protein; Plasma membrane adaptor AP2 17 kDa protein; Sigma adaptin 3b; Sigma2 adaptin; sigma2-adaptin; clathrin coat-associated protein AP17; adaptor protein complex AP-2 subunit sigma; plasma membrane adaptor AP-2 17 kDa p; AP17-DELTA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AP2S1 Related Articles
AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | UBE2L6;IGKC;NPEPPS;IGHM;ASB13;STUB1;GM11711;CD200;CHUK |
| Axon guidance | DUSP10;TRPC4;SEMA4A;EFNA1;DPYSL3;SPRED3;SEMA6A;COL4A3;SCN4A |
| Beta-catenin independent WNT signaling | RYK;AP2A1;CTNNB2;DVL3;AP2S1;CLTA;AGO1;CLTB;DVL2 |
| Developmental Biology | BNIP2;MED25;COL6A2;EPHB4A;SCN4A;DPYSL5A;CD24;ARPC3;PEA15 |
| Disease | MMADHC;TRAT1;RNF43;GYG2;JAG1;STRA6;FDXR;OPN1SW;PSIP1 |
| EGFR downregulation | STAM2;SPRY2;PTPRK;AP2A2;AP2A1;AP2M1;AP2B1;AP2S1;SPRY1 |
| EPH-Ephrin signaling | EFNA4;EPHA4A;AP2S1;EFNB3B;ARHGEF28;ACTR2;EPHB4A;ARPC3;ARPC2 |
| EPH-ephrin mediated repulsion of cells | EFNB2;EFNA3;EPHB3A;EFNA1A;EFNA5;EPHA4A;EFNA1B;EPHB4B;EPHA2 |
AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to clathrin adaptor activity | AP2M1;AP2S1;AP2B1;AP2A2;AP2A1 |
| protein binding | RPL27A;FBXW9;PDZD3;MYBPC2;HOOK2;GRN;CST1;NBL1;SLC6A3 |
| protein transporter activity | DPY19L2;KPNA1;ITGB1BP1;CALCRL;AP4B1;TMCO6;KPNA5;TNPO3;SNUPN |
| transporter activity | TCIRG1;LCN12;AP2M1;ATP5J;PTGDS;ABCB11;TAP2;SLC4A1B;ATP6V0E1 |
AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.
AAGAB; VCAM1; Ap2a1; vpu; TDGF1; EGFR; CLTB; EPS15; NUMB; Smo; GRB2; AP2M1
- Q&As
- Reviews
Q&As (19)
Ask a questionGenetic mutations in the AP2S1 have been shown to be associated with certain genetic diseases.
The AP2S1 is a three-dimensional structure composed of multiple amino acid residues.
AP2S1 is associated with various signaling pathways, such as EGFR signaling pathway and Notch signaling pathway.
There is currently insufficient evidence to support recombinant AP2S1 as a diagnostic marker for tumors.
The AP2S1 is involved in protein breakdown and transport in the cell.
The study of AP2S1 is of great significance for the research and development of new drugs, which can provide new ideas and directions for the discovery of drug targets.
Immunohistochemistry, Western blot and other methods can be used to detect the expression level of AP2S1 .
Some studies have shown that AP2S1 may play a role in tumorgenesis by influencing cell proliferation and metastasis.
There are currently no gene therapy studies involving recombinant AP2S1.
Recombinant protein AP2S1 may be a potential target for tumor therapy, but further research and validation are needed.
There has not been much research on the interaction of AP2S1 with drugs.
The AP2S1 may be one of the targets for drug development, but further studies are needed to confirm it.
The AP2S1 is widely distributed in the human body, including the nervous system and several organs.
The AP2S1 plays a key role in many diseases such as nervous system diseases and tumors.
The current drug development targeting AP2S1 is still in the preliminary stage, and further research and development is needed.
The association of recombinant AP2S1 with certain diseases may have genetic characteristics.
Recombinant AP2S1 protein is expressed in a variety of cell types.
Some studies have shown that recombinant AP2S1 may be involved in regulating synaptic transmission and other functions in nervous system diseases.
The AP2S1 may be a potential target for the treatment of this disease, but further studies are needed to confirm it.
Customer Reviews (4)
Write a reviewCatalytic activity of AP2S1 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is huge.
Experimenting with this recombinant protein allows me to focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.
Quality of AP2S1 is consistent, and we're reassured.
Stability of AP2S1 is highly praised, and it can maintain its structural and functional stability even under various extreme environments, which is really impressive.
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