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ATP6V0D1

Official Full Name

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.
Synonyms

ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; ATP6D, ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D , ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1 , ATPase, H+ transporting, lysosomal 38kDa,;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
MYC
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V0D1-10037H	Recombinant Human ATP, His-tagged	E.coli	His	1-351a.a.	$319 / 25ug
Human	ATP6V0D1-997H	Recombinant Human ATP6V0D1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6V0D1-8588HCL	Recombinant Human ATP6V0D1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP6V0D1-1868H	Recombinant Human ATP6V0D1 protein, GST-tagged	E.coli	GST	1-351 aa	$319 / 25ug
Human	ATP6V0D1-1091HF	Recombinant Full Length Human ATP6V0D1 Protein, GST-tagged	In Vitro Cell Free System	GST	351 amino acids	Inquiry
Mouse	ATP6V0D1-2154M	Recombinant Mouse ATP6V0D1 Protein	Mammalian Cell	His		Inquiry
Mouse	ATP6V0D1-871M	Recombinant Mouse ATP6V0D1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ATP6V0D1-871M-B	Recombinant Mouse ATP6V0D1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Atp6v0d1-672M	Recombinant Mouse Atp6v0d1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Zebrafish	ATP6V0D1-10021Z	Recombinant Zebrafish ATP6V0D1	Mammalian Cell	His		Inquiry
Chicken	ATP6V0D1-5584C	Recombinant Chicken ATP6V0D1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ATP6V0D1 Related Articles

ATP6V0D1 involved in several pathways and played different roles in them. We selected most pathways ATP6V0D1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	ATP5G3A;NDUFA12;ATP6V0A2;NDUFS1;COX7A3;NDUFB7;NDUFA9;NDUFB3;COX6A2
Metabolic pathways	TKTB;CKMT2B;IDI1;GMPPAB;POLR3GL;ENO2;TDO2A;COX7B2;POLR1D
Lysosome	ATP6V0C;ATP6V0A1;CTSJ;SMPD1;CD68;NEU1;ACP2;ATP6V0A1A;ATP6V0A4
Phagosome	MHC2A;C3A.1;NOX3;C3A.3;NOX1;HLA-DOA;TUBB2A;CD36;ITGA5
Synaptic vesicle cycle	DNM3;SYT1;SNAP25;ATP6V0A1;UNC13C;ATP6V1E2;ATP6V0D1;STXBP1;ATP6V1C1
Collecting duct acid secretion	ATP6V0E2;ATP6V1G2;ATP6V1E2;ATP6V0A1;ATP6V1C1;SLC4A1;ATP6V1D;ATP6V1E1;CLCNKB
Vibrio cholerae infection	ATP6V0D2;TJP2;PRKCA;ATP6V1E2;ATP6V1A;GNAS;ERO1L;PDIA4;ACTB
Epithelial cell signaling in Helicobacter pylori infection	JAM2;MAPK10;MAPK13;PTPN11;ATP6V0A1;RELA;ADAM17;ATP6V1G1;ATP6V0D2
Tuberculosis	TLR9;IFNA8;MAPK12;CALM3;CD209B;TLR2;Itgam&Itgb2;SPHK2;CD209C
Viral carcinogenesis	PRKACG;HIST1H2BF;MRPS18B;TRAF2;HIST1H4K;HDAC9;EP300;HLA-A;RB1
Rheumatoid arthritis	LTB;HLA-DMA;HLA-DMB;CXCL5;ATP6V1G2;ATP6V0E2;ATP6V1E2;ATP6V0A1;CXCL12

ATP6V0D1 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0D1 itself. We selected most functions ATP6V0D1 had, and list some proteins which have the same functions with ATP6V0D1. You can find most of the proteins on our site.

Function	Related Protein
hydrogen-exporting ATPase activity, phosphorylative mechanism	ATP6V1E2;ATP6V1C1;ATP6V1G3;ATP6V1G1;ATP6V0D1;ATP6V1E1;ATP6V1C2
protein binding	NEK3;YIPF3;NDFIP1;IGSF8;PSMD2;ING4;HSPB8;KLK15;CDT1
protein complex binding	CDK5RAP1;NCKAP1;COG2;UFD1L;GRIN2A;RBM10;PPIB;ING2;NR0B2

ATP6V0D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0D1.

ATXN1; pi3p; Ccdc9; ATP6AP2; A2M; CDK1; PTPN1; Rab5c; Bmpr1a; TMPO; Vps4b; RAB5C; RAB7A; RAB2A; Cbx1; CLTC; Rmdn3; TMEM63B; Ptpn23; RFWD3

Pacheco-Costa, R; Hassan, I; et al. High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:8508-8520(2014).

Chung, JY; Yi, JW; et al. Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia. JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 50:173-178(2011).