CACYBP
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Official Full Name
calcyclin binding protein
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Overview
Calcyclin-binding protein or Siah-1-interacting protein (CACYBP/SIP) is a component of the ubiquitin E3 ligase complex that also contains Siah1, Skp1, and Ebi. CACYBP regulates beta-catenin turnover and plays an important role in thymocyte development. CA -
Synonyms
CACYBP; calcyclin binding protein; calcyclin-binding protein; S100A6BP; SIP; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; GIG5; PNAS-107; RP1-102G20.6; MGC87971;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CACYBP Related Articles
CACYBP involved in several pathways and played different roles in them. We selected most pathways CACYBP participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACYBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | WNT11;WNT5A;FZD2;DAAM1B;FZD8B;PRKACBA;SIAH2L;CTNNBIP1;CAMK2B |
CACYBP has several biochemical functions, for example, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACYBP itself. We selected most functions CACYBP had, and list some proteins which have the same functions with CACYBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRIM50;ATG13;DHX32;LAMTOR2;RSAD2;BBS2;AGBL4;CBLL1;EMP1 |
| protein homodimerization activity | TIGIT;PDGFA;NADKD1;MUC13;CIDEA;CCDC88A;ABCB9;BNIP3L;PRDX4 |
CACYBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACYBP here. Most of them are supplied by our site. Hope this information will be useful for your research of CACYBP.
SIAH1; SKP1; VCAM1; b3kv54_human; 40040348; AP3D1; CFLAR; TET3; EIF1B; TBL1X; FBXO24; URI1; REC8
- Q&As
- Reviews
Q&As (5)
Ask a questionPhosphorylation of CACYBP can modulate its protein-protein interactions and stability. Phosphorylation events may affect its role in cell cycle regulation and ubiquitin-dependent protein degradation.
CACYBP's calcium-binding domains undergo conformational changes upon calcium binding, which can affect its interactions with other proteins. It allows CACYBP to act as a calcium-dependent scaffold for various signaling complexes.
CACYBP interacts with Cyclins and CDKs, forming complexes that regulate the phosphorylation of key cell cycle regulators. These interactions affect the progression through different phases of the cell cycle.
CACYBP functions as an adaptor protein in ubiquitin-dependent protein degradation by facilitating the transfer of ubiquitin moieties to target proteins. It forms complexes with E3 ubiquitin ligases and substrates, directing them to the proteasome for degradation.
CACYBP participates in stress responses by modulating the stability and activity of proteins involved in stress pathways. For example, it can influence the stability of DNA repair proteins and oxidative stress response factors, contributing to cellular adaptation to stress conditions.
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