capns2
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  • Official Full Name
  • calpain, small subunit 2
  • Background
  • Both M-calpain and m-calpain are ubiquitously expressed in mammalian cells, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain-3, calpain-5, calpain-9, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain-S1), and a large variable subunit. It is not clear that all calpains form heterodimers with a small subunit, but calpain-S1 is known to form a heterodimer with calpain-1 and also with calpain-2. Calpain S2 was recently discovered, and initial studies indicate that both small subunits may act as chaperonins to help with folding, or accessory proteins to help localize the calpains. Domains in the small subunit include the amino terminal domain-V (a glycine-rich sequence that is removed on activation of calpain, shorter in calpain-S2 than in calpain S1) and domain-VI, the calcium binding, EF hand domain.
  • Synonyms
  • CAPNS2; calpain, small subunit 2; calpain small subunit 2; CSS2; calcium-dependent protease small subunit 2;
Cat.#:CAPNS2-0375HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAPNS2 Protein, GST-Tagged
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Cat.#:CAPNS2-10708HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAPNS2, GST-tagged
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Cat.#:CAPNS2-2702MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAPNS2 Protein
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Cat.#:CAPNS2-7858HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAPNS2 293 Cell Lysate
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Involved Pathway

CAPNS2 involved in several pathways and played different roles in them. We selected most pathways CAPNS2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPNS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
C20orf20; RBB4L; KDM1A; KDM5BB; SMARCA2; KDM4C; KDM6B; EP400; JADE1; ACTL6B
Chromatin organization
MBD3B; CHD4A; BRD1; ACTL6B; KDM4C; MBD3; ACTL6A; SMARCD3B; KANSL2; TADA2A
HATs acetylate histones
MORF4L2; PHF15; MSL1A; DR1; MSL2A; KAT7A; MSL2B; MCRS1; BRD1; MBIP

Protein Function

CAPNS2 has several biochemical functions, for example, chromatin binding, methylated histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPNS2 itself. We selected most functions CAPNS2 had, and list some proteins which have the same functions with CAPNS2. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein HIF1AB; TGIF1; SP100; PELP1; TADA2B; PCGF2; UXT; WDHD1; ING2; PCNA
Function methylated histone binding
Related Protein FAM156A; ING2; MSL3; JHDM1D; RBBP5; CDYL2; SUZ12; ATRX; L3MBTL1; DPPA3
Function protein binding
Related Protein VPS41; FAM158A; BMI1; MTERFD2; IL4; DUSP14; SYN1; PSME3; WBP2NL; BBS10
Function zinc ion binding
Related Protein ANPEPB; KDM2A; TRAF7; TRIM43B; Alb; ABLIM3; PPARAA; RBM4; SNCA; ZCCHC9

CAPNS2 Related Articles

Osugi, K; Suzuki, H; et al. Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins. JOURNAL OF BIOCHEMISTRY 151:657-666(2012).
Iguchi-Hashimoto, M; Usui, T; et al. Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kappa B and Increased STAT5 Signals. PLOS ONE 6:-(2011).