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CAPNS2

Official Full Name

calpain, small subunit 2
Overview

Both M-calpain and m-calpain are ubiquitously expressed in mammalian cells, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain-3, calpain-5, calpain-9, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain-S1), and a large variable subunit. It is not clear that all calpains form heterodimers with a small subunit, but calpain-S1 is known to form a heterodimer with calpain-1 and also with calpain-2. Calpain S2 was recently discovered, and initial studies indicate that both small subunits may act as chaperonins to help with folding, or accessory proteins to help localize the calpains. Domains in the small subunit include the amino terminal domain-V (a glycine-rich sequence that is removed on activation of calpain, shorter in calpain-S2 than in calpain S1) and domain-VI, the calcium binding, EF hand domain.
Synonyms

CAPNS2; calpain, small subunit 2; calpain small subunit 2; CSS2; calcium-dependent protease small subunit 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CAPNS2-10708H	Recombinant Human CAPNS2, GST-tagged	E.coli	GST	5-248a.a.	$319 / 25ug
Human	CAPNS2-0375H	Recombinant Human CAPNS2 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CAPNS2-7858HCL	Recombinant Human CAPNS2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CAPNS2-6041H	Recombinant Human CAPNS2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CAPNS2-2831HF	Recombinant Full Length Human CAPNS2 Protein, GST-tagged	In Vitro Cell Free System	GST	248 amino acids	Inquiry
Mouse	CAPNS2-2702M	Recombinant Mouse CAPNS2 Protein	Mammalian Cell	His		Inquiry
Mouse	Capns2-1954M	Recombinant Mouse Capns2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	CAPNS2-1223M-B	Recombinant Mouse CAPNS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CAPNS2-1223M	Recombinant Mouse CAPNS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CAPNS2 Related Articles

CAPNS2 involved in several pathways and played different roles in them. We selected most pathways CAPNS2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPNS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	COPRS;SAP18;PHF2;SMARCB1B;C3orf75;MSL1;GATAD2AB;JADE1;HIST2H3C
Chromatin organization	KDM7AB;KDM5BB;TADA3;PRDM16;SMARCC1B;SAP18;ASH2L;CARM1;JADE1
HATs acetylate histones	EP400;ANO9A;PHF17;ZZZ3;SAP130;TADA2A;KAT8;KANSL2;CSRP2BP

CAPNS2 has several biochemical functions, for example, chromatin binding, methylated histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPNS2 itself. We selected most functions CAPNS2 had, and list some proteins which have the same functions with CAPNS2. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	PRKCBB;HMG20A;TOP1;PRIMPOL;AIRE;SMAD6;POLA1;RAD51;SIRT7
methylated histone binding	TP53BP1;GLYR1;CBX7;ATRX;CAPNS2;CDYL2;UHRF1;LOXL2;ZMYND11
protein binding	MAGED1;PSMC1;LBX1;MPZL1;WDR61;RIPK1;GP6;TAB2;PPP4R4
zinc ion binding	PCGF2;S100A8;RABGGTB;RUNX1;MARCH5L;RNF166;ADAMTS7;MSL2;NR2F6A

CAPNS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPNS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPNS2.

Osugi, K; Suzuki, H; et al. Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins. JOURNAL OF BIOCHEMISTRY 151:657-666(2012).

Iguchi-Hashimoto, M; Usui, T; et al. Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kappa B and Increased STAT5 Signals. PLOS ONE 6:-(2011).