cct4
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  • Official Full Name
  • chaperonin containing TCP1, subunit 4 (delta)
  • Background
  • The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2;back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly;translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded;intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM;191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 (PubMed 9819444)).
  • Synonyms
  • CCT4; chaperonin containing TCP1, subunit 4 (delta); T-complex protein 1 subunit delta; Cctd; TCP-1-delta; stimulator of TAR RNA-binding; chaperonin containing t-complex polypeptide 1, delta subunit; SRB; CCT-DELTA; MGC126164; MGC126165
Cat.#:CCT4-0712HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCT4 Protein, GST-Tagged
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Cat.#:CCT4-10897HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCT4, His-tagged
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Cat.#:CCT4-27952THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCT4, His-tagged
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Cat.#:CCT4-3025MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCT4 Protein
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Cat.#:CCT4-1233RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCT4 Protein
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Cat.#:CCT4-7090CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCT4
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Cat.#:CCT4-10861ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCT4
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Cat.#:CCT4-7688HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCT4 293 Cell Lysate
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Involved Pathway

CCT4 involved in several pathways and played different roles in them. We selected most pathways CCT4 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
BBS12; ODF2B; CCP110; MARK4; CLASP1A; FGFR1OP; FLR; IFT27; CEP78; AKAP9
Association of TriC/CCT with target proteins during biosynthesis
CCT6A; CCT2; FBXW2; NOP56; KIFC3; TCP1; FBXW4; FBXW5; FBXW9; CCT7
BBSome-mediated cargo-targeting to cilium
CCT4; BBS2; SETD6; TCP1; CCT3; PROL1; RAB3IP; CCT8; BBS5; CCT2
Cargo trafficking to the periciliary membrane
BBS7; PROL1; TCP1; UNC119B; ARL3; RHOL; ARF4; ARL13B; BBS1; EXOC6
Chaperonin-mediated protein folding
PFDN5; KIFC3; TCP1; CCT3; TUBB4B; TUBB4A; CCT7; PFDN4; FBXW9; PFDN2
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
PFDN1; TUBB4A; CCT2; PFDN2; CCT3; CCT7; PFDN6; TCP1; VBP1; PFDN4
Folding of actin by CCT/TriC
CCT7; CCT5; CCT2; CCT8; CCT6A; TCP1; CCT3; CCT4
Formation of tubulin folding intermediates by CCT/TriC
CCT3; TUBA3D; TUBB4A; CCT7; TUBB4B; TCP1; CCT5; CCT2; CCT6A; CCT8

Protein Function

CCT4 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT4 itself. We selected most functions CCT4 had, and list some proteins which have the same functions with CCT4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EPHA2A; ATP6V1A; PRKCHA; CDK18; CAMK1D; HSPA5; ATP13A; PINK1; ATP2B3B; RIPK1
Function poly(A) RNA binding
Related Protein KRT18; RPS5; DHX30; SRSF7; NOVA1; ILF3; SCAF4; SNRPD3; U2SURP; SLC25A11
Function protein binding
Related Protein MYBPH; ALDH18A1; RCOR1; SLC6A12; DPM2; FBN1; ARAP1; FAM111A; PDGFA; EEF1A1
Function unfolded protein binding
Related Protein DNAJB13; HSPD1; TUBB4B; CRYABA; CLN3; CALR3; AHSP; TCP1; HSPA1L; CLPXA

Interacting Protein

CCT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT4.
PPP4C; PPP2CB; PPP2CA; STRN3; ILK; OLR1; STRN