cops3
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  • Official Full Name
  • COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
  • Background
  • The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • COPS3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3; COP9 signalosome complex subunit 3; CSN3; SGN3; signalosome subunit 3; COP9 complex subunit 3; JAB1-containing signalosome subunit 3
Cat.#:COPS3-1702HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COPS3 Protein, GST-tagged
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Cat.#:COPS3-3780MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COPS3 Protein
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Cat.#:COPS3-1533RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COPS3 Protein
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Cat.#:COPS3-1314CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COPS3
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Cat.#:COPS3-10083ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COPS3
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Cat.#:COPS3-7358HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COPS3 293 Cell Lysate
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Involved Pathway

COPS3 involved in several pathways and played different roles in them. We selected most pathways COPS3 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
COPS6; COPS2; PARP2; NFRKB; PARP1; INO80B; COPS7A; COPS5; COPS8; DDB2
DNA Repair
CHEK1; INO80E; UBE2V2; COPS6; RAD1; CETN2; ELL; PNKP; RAD9B; UBE2L6
Formation of TC-NER Pre-Incision Complex
GPS1; COPS3; DDB1; ZNF830; COPS5; COPS7B; COPS8; COPS6; ERCC8; KIAA1530
Global Genome Nucleotide Excision Repair (GG-NER)
COPS4; COPS2; COPS7A; CHD1L; PARP2; ACTL6A; PIAS3; YY1A; DDB2; COPS8
Nucleotide Excision Repair
RAD23AB; POLE; COPS8; COPS6; PCNA; ZNF830; RPA2; ERCC3; CCNH; RBX1
TNF-alpha/NF-kB Signaling Pathway
COMMD1; KTN1; SMARCC2; CAPN3; MCC; DPF2; DDX3X; TRPC4AP; SMARCE1; NKIRAS2
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
ZFP830; COPS4; PPIE; COPS6; KIAA1530; COPS8; COPS2; GPS1; COPS7A; COPS7B

Protein Function

COPS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS3 itself. We selected most functions COPS3 had, and list some proteins which have the same functions with COPS3. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SHMT2; SCRN1; TGFB1I1; NKRF; LNX1; MYL2; PIBF1; DIS3L; BCL2L13; RBM10

Interacting Protein

COPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS3.
COPS5; COPS6; COPS7A

COPS3 Related Articles

McMichael, G; Girirajan, S; et al. Rare copy number variation in cerebral palsy. EUROPEAN JOURNAL OF HUMAN GENETICS 22:40-45(2014).
Goossens, DJ; Brazier-Hollins, S; et al. Magnetic structure and glassiness in Fe0.5Ni0.5PS3. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 334:82-86(2013).