derl1
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  • Official Full Name
  • Der1-like domain family, member 1
  • Background
  • Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the DERL1 gene . It is a member of the rhomboid-like clan of polytopic membrane proteins.
  • Synonyms
  • DERL1; Der1-like domain family, member 1; derlin-1; DER 1; DER1; derlin 1; FLJ13784; MGC3067; PRO2577; DERtrin-1; der1-like protein 1; degradation in endoplasmic reticulum protein 1; DER-1; FLJ42092
Cat.#:DERL1-2546HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DERL1 Protein, GST-tagged
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Cat.#:DERL1-4523MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DERL1 Protein
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Cat.#:DERL1-1244RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DERL1 Protein, His-tagged
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Cat.#:DERL1-1494CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DERL1
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Cat.#:DERL1-12615ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DERL1
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Cat.#:DERL1-6971HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DERL1 293 Cell Lysate
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Involved Pathway

DERL1 involved in several pathways and played different roles in them. We selected most pathways DERL1 participated on our site, such as Protein processing in endoplasmic reticulum, Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
ATF4; LMAN1L; MBTPS2; HSPA4L; DNAJC1; NFE2L2; MAP2K7; SEC61G; PDIA3; GSBP9
Amyotrophic lateral sclerosis (ALS)
TOMM40L; GRIA2; PPP3CB; TNFRSF1A; CAT; CYCS; BAD; PPP3R1; MAPK13; MAPK11

Protein Function

DERL1 has several biochemical functions, for example, ATPase binding, MHC class I protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL1 itself. We selected most functions DERL1 had, and list some proteins which have the same functions with DERL1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein LCK; TOR1AIP1; NR1H2; ZNHIT6; CHRNA7; ANK1; ATP1B2; ATP6V0A2B; PDE4D; ABCA1
Function MHC class I protein binding
Related Protein PILRB2; ATP5B; PILRB; DERL1; BCAP31; VCP; CD244; LILRB2; LILRB1; CD8B
Function protease binding
Related Protein CFLAR; MBP; DPP4; NDUFS7; BCL10; ADAMTS4; ADAM8A; F3; INS; TIMP3
Function protein binding
Related Protein CTNNB2; PLSCR1; GNL3; RAD52; BSX; CD1B; GPRIN2; MERTK; RYBP; SIRPB1
Function receptor activity
Related Protein ABP1; NRXN1; MED13; PAQR5A; TNPO3; VMN1R41; EPHB6; EIF2D; TNFRSF10A; VMN1R54
Function ubiquitin protein ligase binding
Related Protein GABARAPL1; TANK; GABARAP; TRAF5; MC4R; MOAP1; MUL1; UBE2KB; UBE2O; YWHAE
Function ubiquitin-specific protease binding
Related Protein CHMP3; AMFR; BAG6; VCP; DERL1; RAD23A; VPS24; SYVN1; PARK7; SELS

Interacting Protein

DERL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL1.
TCF25; HM13; CFTR; BCAP31; VIMP; XBP1; ALB; US11; VCP