DERL2
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Official Full Name
Der1-like domain family, member 2
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Overview
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the;homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006;(PubMed 16449189)). -
Synonyms
DERL2; Der1-like domain family, member 2; derlin-2; CGI 101; derlin 2; F LAN 1; F LANa; FLANa; Carcinoma related; Degradation in endoplasmic reticulum protein 2; DER 2; Der1 like domain family member 2; DER2; DERL 2; Derlin2; DERtrin 2; DERtrin2; DERtrin-2; OTTHUMP00000128204; der1-like protein 2; F-LANa; CGI-101; F-LAN-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DERL2-984H | Recombinant Human DERL2 | Mammalian Cell | His | ||
Human | DERL2-11941H | Recombinant Human DERL2, His-tagged | E.coli | His | 1-70a.a. | |
Human | DERL2-6970HCL | Recombinant Human DERL2 293 Cell Lysate | HEK293 | N/A | ||
Human | DERL2-2389H | Recombinant Human DERL2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | DERL2-2791H | Recombinant Human DERL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | DERL2-2791H-B | Recombinant Human DERL2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Derl2-584M | Recombinant Mouse Derl2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Dictyostelium discoideum (Slime mold) | RFL31419DF | Recombinant Full Length Dictyostelium Discoideum Probable Derlin-2 Homolog(Derl2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-254) | |
Homo sapiens (Human) | RFL32737HF | Recombinant Full Length Human Derlin-2(Derl2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-239) | |
Mus musculus (Mouse) | RFL24828MF | Recombinant Full Length Mouse Derlin-2(Derl2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-239) | |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL33857PF | Recombinant Full Length Pongo Abelii Derlin-2(Derl2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-239) | |
Rhesus Macaque | DERL2-1245R | Recombinant Rhesus monkey DERL2 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | DERL2-1070R | Recombinant Rhesus Macaque DERL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | DERL2-1070R-B | Recombinant Rhesus Macaque DERL2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | DERL2-3002Z | Recombinant Zebrafish DERL2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
DERL2 involved in several pathways and played different roles in them. We selected most pathways DERL2 participated on our site, such as Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Asparagine N-linked glycosylation | TMED2;OS9;CTSC;SLC35A1;NEU3;TRAPPC3;MPDU1B;DERL2;MLEC |
Calnexin/calreticulin cycle | MAN1B1;OS9;DERL2 |
Disease | HDAC5;AP2B1;CHMP4C;FGFR1OP2;EEF2;TLR6;BANF1;MMAA;CDC37 |
Diseases of signal transduction | MIB1;TTR;CDC37;OPN1LW;RBP1;TNKS;KREMEN2;CTBP1;HEY1 |
ER Quality Control Compartment (ERQC) | DERL2;MAN1B1;OS9 |
Hedgehog ligand biogenesis | GPC5A;OS9;NOTUM;NOTUM1A;DERL2;SCUBE2;HHAT;DISP2 |
Hh mutants abrogate ligand secretion | DERL2;OS9 |
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD | DERL2;OS9 |
DERL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL2 itself. We selected most functions DERL2 had, and list some proteins which have the same functions with DERL2. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | KDRL;KIAA1143;DEDD2;ATP5F1;DNASE1;ETV4;PYCRL;PDE4DIP;EP300 |
DERL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL2.
KRTAP10-7; KRTAP10-8; Dlg4; Kcnk1; Smn1; REEP5; TMEM63B; Kctd5; MASTL; Hspa14; FZD1
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