Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

DMRT1

Official Full Name

doublesex and mab-3 related transcription factor 1
Overview

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like;DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining;pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific;and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene;is hemizygous.
Synonyms

DMRT1; doublesex and mab-3 related transcription factor 1; doublesex- and mab-3-related transcription factor 1; DM domain expressed in testis 1; DMT1; DM domain expressed in testis protein 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DMRT1-27093TH	Recombinant Human DMRT1	Wheat Germ	N/A	373 amino acids	Inquiry
Human	DMRT1-2709H	Recombinant Human DMRT1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DMRT1-6898HCL	Recombinant Human DMRT1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DMRT1-4029HF	Recombinant Full Length Human DMRT1 Protein, GST-tagged	In Vitro Cell Free System	GST	373 amino acids	Inquiry
Human	DMRT1-6242H	Recombinant Human DMRT1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	DMRT1-128HF	Recombinant Full Length Human DMRT1 Protein	In Vitro Cell Free System		373 amino acids	Inquiry
Mouse	DMRT1-4649M	Recombinant Mouse DMRT1 Protein	Mammalian Cell	His		Inquiry
Mouse	DMRT1-2414M	Recombinant Mouse DMRT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	DMRT1-2414M-B	Recombinant Mouse DMRT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Dmrt1-2587M	Recombinant Mouse Dmrt1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	DMRT1-11663Z	Recombinant Zebrafish DMRT1	Mammalian Cell	His		Inquiry
Zebrafish	DMRT1-11775Z	Recombinant Zebrafish DMRT1	Mammalian Cell	His		Inquiry
Chicken	DMRT1-3742C	Recombinant Chicken DMRT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DMRT1 Related Articles

DMRT1 involved in several pathways and played different roles in them. We selected most pathways DMRT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DMRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

DMRT1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMRT1 itself. We selected most functions DMRT1 had, and list some proteins which have the same functions with DMRT1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	E2F7;FOXF1;NEUROD2;NR1D1;ZNF583;MSX1;TBX5;POU3F4;PHOX2B
chromatin binding	HDAC3;TRP53;TCF3;HINFP;KLHDC3;HESX1;POLA1;RAN;NOC3L
core promoter proximal region sequence-specific DNA binding	DMRT2B;SMAD3;KLF1;ZFP516;MIXL1;DMRTC2;TFAP2A;UHRF1;SP3
metal ion binding	ITPA;ZNF800B;KITA;ZNF549;PLRDGB;ZBTB24;ZNF426;ZFP12;ISL1L
protein heterodimerization activity	BAXA;EXT2;HIST1H2AC;TPD52;SDCBP2;CLNS1A;MID2;UGT1A1;HIST1H2A9
protein homodimerization activity	ACHE;SMAD4;VPS25;TFAP2B;TWIST1;CRYBB2;MTERFD3;MTPAP;ATPIF1
transcription factor activity, sequence-specific DNA binding	HNF1B;TBX5B;TRP53;ELF2;RUNX3;KLF9;ZKSCAN3;CREMB;NFE2L2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	OSR2;MAFBA;IRF2;ONECUT3;CSRNP3;CSRNP2;DMRT1;PKNOX1;HSF2

DMRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMRT1.

Dlg4

Li, XY; Li, Z; et al. Expression characterization of testicular DMRT1 in both Sertoli cells and spermatogenic cells of polyploid gibel carp. GENE 548:119-125(2014).

Liu, MX; Hu, ZB; et al. Scanning of novel cancer/testis proteins by human testis proteomic analysis. PROTEOMICS 13:1200-1210(2013).