ercc5
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  • Official Full Name
  • excision repair cross-complementing rodent repair deficiency, complementation group 5
  • Background
  • This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
  • Synonyms
  • ERCC5; excision repair cross-complementing rodent repair deficiency, complementation group 5; ERCM2, xeroderma pigmentosum, complementation group G , XPGC; DNA repair protein complementing XP-G cells; Cockayne syndrome; COFS 3; COFS3; DNA excision repair protein ERCC 5; DNA excision repair protein ERCC5; DNA repair protein complementing XP G cells; DNA repair protein complementing XPG cells; ERCC 5; ERCM 2; ERCM2; Excision Repair Cross Complementing Rodent Repair Deficiency; Excision repair cross complementing rodent repair deficiency complementation group 5; Excision repair protein; OTTHUMP00000064902; UVDR; Xeroderma Pigmentosum Complementation Group G; Xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G complementing protein; XPG; XPG complementing protein; XPGC; OTTHUMP00000018678; XPG-complementing protein; DNA excision repair protein ERCC-5; xeroderma pigmentosum, complementation group G
Cat.#:ERCC5-1900HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC5 protein, His-tagged
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Cat.#:ERCC5-6563HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERCC5 protein, MYC/DDK-tagged
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Cat.#:ERCC5-3281CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERCC5
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Cat.#:ERCC5-6563HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC5 293 Cell Lysate
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Involved Pathway

ERCC5 involved in several pathways and played different roles in them. We selected most pathways ERCC5 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
POLE4; COPS3; GPS1; YY1A; ERCC5; RAD23B; COPS5; BIVM-ERCC5; CHD1L; RFC3

Protein Function

ERCC5 has several biochemical functions, for example, bubble DNA binding, double-stranded DNA binding, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC5 itself. We selected most functions ERCC5 had, and list some proteins which have the same functions with ERCC5. You can find most of the proteins on our site.
Function
Related Protein
Function bubble DNA binding
Related Protein WRN; ERCC5; HMGB1; RECQL4; BLM; NEIL3
Function double-stranded DNA binding
Related Protein RAD51AP1; YBX1; HLF; RAD51B; LSM14A; RAD51; TP73; RAD51L3; HMGB3; SATB1
Function endodeoxyribonuclease activity
Related Protein DNASE1L1; ERCC5; DNASE1L3; ERCC4; RPS3; DNASE1; APLF; APEX1; MBD4; MRE11A
Function metal ion binding
Related Protein SMAD4; CYP2P9; BRCC3; ZBTB20; GMEB1; TRIM35-28; ICN; POLM; GTPBP8; PFKP
Function protein N-terminus binding
Related Protein SMARCA4; TDRD7; LACRT; GTF2H3; EXOC4; DCN; TGFB1; HDAC1; STXBP1; PARP1
Function protein binding
Related Protein SCN11A; LGALS9C; EFTUD2; TBCD; SMC1A; PGBD1; CTAGE5; BAI3; RAB35; GPR177
Function protein homodimerization activity
Related Protein SYT6; ASMT; PYCARD; GSTM4; CBLN1; ABAT; TFAP2A; MID1; HOMER2; RQCD1
Function single-stranded DNA binding
Related Protein PURB; CDC45; XPC; TTC6; TSNAX; FBXO18; OBFC1; LRPPRC; HSPD1; MCM4

Interacting Protein

ERCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC5.
HSPB1; EWSR1; Tpx2; BCL6; LRPPRC; CDK7; Kif1bp; GTF2H5; TGS1; Ndc80