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FARP1

Official Full Name

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Overview

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms

FARP1; FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); FERM, RhoGEF and pleckstrin domain-containing protein 1; CDEP; MGC87400; PLEKHC2; PPP1R75; protein phosphatase 1; regulatory subunit 75; Chondrocyte derived ezrin like protein; FERMRhoGEF and pleckstrin domain containing protein 1; FERM RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); PH domain-containing family C member 2; chondrocyte-derived ezrin-like protein; protein phosphatase 1, regulatory subunit 75; pleckstrin homology domain-containing family C member 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FARP1-3840H	Recombinant Human FARP1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FARP1-596HCL	Recombinant Human FARP1 cell lysate		N/A		Inquiry
Human	FARP1-4709HF	Recombinant Full Length Human FARP1 Protein, GST-tagged	In Vitro Cell Free System	GST	129 amino acids	Inquiry
Human	FARP1-5822H	Recombinant Human FARP1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	FARP1-5680M	Recombinant Mouse FARP1 Protein	Mammalian Cell	His		Inquiry
Mouse	FARP1-3117M	Recombinant Mouse FARP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Farp1-2954M	Recombinant Mouse Farp1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	FARP1-3117M-B	Recombinant Mouse FARP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	FARP1-4537C	Recombinant Chicken FARP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FARP1 Related Articles

FARP1 involved in several pathways and played different roles in them. We selected most pathways FARP1 participated on our site, such as Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Regulation of RhoA activity	ARHGAP9;MYO9B;DEF6;OBSCN;ARAP1;MCF2L;ABR;AKAP13;ARHGEF15

FARP1 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FARP1 itself. We selected most functions FARP1 had, and list some proteins which have the same functions with FARP1. You can find most of the proteins on our site.

Function	Related Protein
Rac guanyl-nucleotide exchange factor activity	SPATA13;ARHGEF4;PREX2;DOCK2;ARHGEF2;VAV3;FARP2;FARP1;VAV1
Rho guanyl-nucleotide exchange factor activity	FGD4;ITSN2A;ECT2;ARHGEF7A;AKAP13;ARHGEF19;PLEKHG3;TIAM2;DOCK10
cytoskeletal protein binding	RPH3AL;NF2B;ALDOA;CAPN2;EPB41B;FABP3;DYNLL2;ANXA2B;MSNA

FARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FARP1.

PPP1CA; Trappc8; ssrna_ag; MYO1C; Flot1; PDGFRA; BRD2; CAPZA2; Flot2; Myh10; Pcbp2; Flnb; Prmt5; Prkar2a; SYNPO; Myh9; AKAP1; GEMIN7; GAR1

Fan, LF; Yan, HJ; et al. The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction. NEUROSCIENCE LETTERS 590:178-183(2015).

Lopez, LM; Hill, WD; et al. Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities. STROKE 46:341-347(2015).