gnb2l1
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
  • Background
  • Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
  • Synonyms
  • GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; Gnb2 rs1; H12.3; RACK1; Receptor for Activated C Kinase 1; lung cancer oncogene 7; proliferation-inducing gene 21; human lung cancer oncogene 7 protein; receptor of activated protein kinase C 1; cell proliferation-inducing gene 21 protein; guanine nucleotide-binding protein subunit beta-like protein 12.3; protein homologous to chicken B complex protein, guanine nucleotide binding; HLC-7; PIG21; Gnb2-rs1
Cat.#:GNB2L1-30327THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNB2L1, His-tagged
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Cat.#:GNB2L1-465HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNB2L1 Protein, His & MBP-tagged
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Cat.#:GNB2L1-7028MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNB2L1 Protein
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Cat.#:GNB2L1-1197CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNB2L1
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Cat.#:GNB2L1-9012ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNB2L1
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Cat.#:GNB2L1-1375HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged
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Cat.#:GNB2L1-5862HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNB2L1 293 Cell Lysate
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Involved Pathway

GNB2L1 involved in several pathways and played different roles in them. We selected most pathways GNB2L1 participated on our site, such as Androgen receptor signaling pathway, BDNF signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2L1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Androgen receptor signaling pathway
EFCAB6; RUNX2A; NR2C2; JUN; TGFB1I1; RHOB; ETV5A; PSMC3IP; SMARCE1; MYST2
BDNF signaling pathway
DPYSL2; CNR1; CDKL5; SIRPA; GRIP1; EEF2; EIF4E; GNB2L1; EIF2S1; CFL1
CXCR4-mediated signaling events
MAPKAP1; CFL1; ADRBK1; CRK; ARR3; PAG1; GNB2L1; GNA13; DNM1; BLK
Death Receptor Signalling
RBCK1; TAX1BP1B; SHRPRBCK1R; USP4; GNB2L1; CLIP3; OTULIN; OTULINB; TAB1; CYLD
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
COPS5; HIF3A; GNB2L1; NAA10; HIF1AN
IGF1 pathway
GNB2L1; GRB10
IL-3 Signaling Pathway
GATA1A; GATA2A; PILRB; SPI1B; GATA2; GNB2L1; GATA1; BIRC5A; KCNIP3B; BMX
Interferon type I
PIAS3; GNB2L1

Protein Function

GNB2L1 has several biochemical functions, for example, SH2 domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2L1 itself. We selected most functions GNB2L1 had, and list some proteins which have the same functions with GNB2L1. You can find most of the proteins on our site.
Function
Related Protein
Function SH2 domain binding
Related Protein DAG1; GNB2L1; LAX1; MS4A2; CRK; INPPL1; LCK; SH3PXD2B; SRC; PAG1
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein APAF1; MAPK9; BCL2L13; RPS27L; CASP1; NLRP12; CARD8; NLRP1; NOD1; GNB2L1
Function enzyme binding
Related Protein NOXA1; IQCB1; DNMT3L; RPS2; AXIN1; PCCA; TRAF2; KALRN; LDB2; TRIO
Function ion channel inhibitor activity
Related Protein ENSA; KCNV1; KCNMB2; GNB2L1; STOML1; PDZD3; RSC1A1
Function poly(A) RNA binding
Related Protein LAS1L; RPS9; CNOT1; SFRS9; C3orf26; ADD1; NLRP11; DHX36; NDUFV3; NCOA5
Function protein binding
Related Protein UBLCP1; C12orf50; BEX1; ERBB2; HBA1; NEDD4L; MRPL15; EXOC7; TAGLN2; CST7
Function protein complex scaffold
Related Protein ISCU; MAP2K2; DLG1; C9orf142; HOMER1; ARRB2; ITSN1; SLC9A3R2; GNB2L1; MAGI3
Function protein homodimerization activity
Related Protein UGT1A9; C16orf89; S100A5; S100A1; AMICA1; HNF1B; HNF4A; PDGFRA; AGR2; TIGIT
Function protein kinase C binding
Related Protein TOP2B; ADD3; TOP2A; SDC4; SDPRB; FLNA; DSP; PAWR; PKN1; TDG
Function protein phosphatase binding
Related Protein EGFR; LCK; CSF1R; PPME1; IRS2; GNB2L1; JUPA; NEK2; EIF2AK3; ANAPC7
Function protein tyrosine kinase inhibitor activity
Related Protein FGFR1OP; IBTK; GNB2L1
Function receptor binding
Related Protein APP; POU2F1; CRAT; BMP2; ACOX2; CADM1A; NPPA; TMEM38A; PCSK1N; SLC27A2
Function receptor tyrosine kinase binding
Related Protein FLT3LG; SQSTM1; PIK3R2; ANXA5; ZNF259; TRP53; NRG1; ARHGEF16; NRG3; MYOC
Function signaling adaptor activity
Related Protein GNB2L1; LDLRAP1; MPP7; AFAP1L2; HOMER1; SH2B1; SH2B3; SH2B2

Interacting Protein

GNB2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2L1.
DYNLL1; VHL; PPID; bzlf1_ebvb9

GNB2L1 Related Articles

Sun, Y; Tao, Y; et al. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. NEUROSCIENCE BULLETIN 31:43-52(2015).
Guiry, A; Flynn, D; et al. Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar). BMC GENOMICS 11:-(2010).