hipk2
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  • Official Full Name
  • homeodomain interacting protein kinase 2
  • Background
  • HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.
  • Synonyms
  • HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; hHIPk2; PRO0593; FLJ23711; DKFZp686K02111
Cat.#:HIPK2-234HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HIPK2 Protein, MYC/DDK-tagged
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Cat.#:HIPK2-249HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HIPK2 Protein, His-tagged
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Cat.#:HIPK2-4761HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human HIPK2 Protein, GST-tagged
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Cat.#:HIPK2-4762HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HIPK2 Protein, GST-tagged
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Cat.#:HIPK2-5797ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HIPK2
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Cat.#:HIPK2-1414MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse HIPK2 (Active), GST-tagged
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Involved Pathway

HIPK2 involved in several pathways and played different roles in them. We selected most pathways HIPK2 participated on our site, such as Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt Signaling Pathway NetPath
ROR2; HIPK2; PAX2; NR5A1; ANKRD6; MAP1B; CSNK2A1P; TAX1BP3; TFAP2A; CRYBB2

Protein Function

HIPK2 has several biochemical functions, for example, ATP binding, NOT DNA binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK2 itself. We selected most functions HIPK2 had, and list some proteins which have the same functions with HIPK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK32C; SPG7; DDX10; GRK7; MAT2AL; ABCB9; TTBK1; NSFB; TOP2A; MST1R
Function NOT DNA binding
Related Protein NFIB; HIPK2; SKIL; TINF2; MBD5; XRCC4
Function RNA polymerase II activating transcription factor binding
Related Protein SETD3; EGR2; BHLHE40; T; HNF4A; NHLH2; NFE2L2; SMAD3; TBX20; HEY2
Function contributes_to RNA polymerase II transcription coactivator activity
Related Protein WWOX; HIPK2
Function SMAD binding
Related Protein SKI; SKOR1B; COL1A2; MAGI2; SKILB; HIPK2; YY1; TCF12; ACVR1; PURA
Function kinase activity
Related Protein PRKCHA; TGFBR1B; BMPR1BB; PTK2BB; GRK1A; INSRA; PKDCCA; MARCKSB; MAPK8A; CCL3
Function nucleotide binding
Related Protein RHOGB; SRSF6A; SMC2; CAMK1DB; RAB32A; U2AF2A; SRSF4; C10orf28; PPARGC1B; RND3A
Function protein binding
Related Protein C19orf57; SAP30BP; ISY1; DULLARD; ADAM33; VCL; NPY2R; SLX1B; CCR1; PDLIM3
Function protein kinase activity
Related Protein MAP2K1; GSG2; MAP3K5; WEE2; CAMKK1B; PAK4; SMOK2B; MKNK2B; SYK; NPR2
Function protein serine/threonine kinase activity
Related Protein GM711; PRKG1A; MAP2K3; TAF1; TRIOA; MAP3K2; GRK5; SMOK3A; PRKCE; PRKCHA
Function transcription corepressor activity
Related Protein LHX1; MECP2; NANOG; NRIP1; ZHX3; E2F7; SMARCA4; SIRT1; ZFPM2; SIAH2
Function transferase activity
Related Protein MAP2K2A; GSBP9; NTMT1; B3GALTLB; SULT1ST1; PNP5B; UBE2D2A; B3GNT9-PS; SAT1A.2; HAS2
Function virion binding
Related Protein CLEC4M; CD209; PTX3; PVRL1; HIPK2; HSP90B1; APCS; TSG101; PPIA

HIPK2 Related Articles

Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
Puca, R; Nardinocchi, L; et al. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. CELL CYCLE 10:1679-1689(2011).