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HIPK2

  • Official Full Name

    homeodomain interacting protein kinase 2

  • Overview

    HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.
  • Synonyms

    HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; hHIPk2; PRO0593; FLJ23711; DKFZp686K02111;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIPK2-234H Recombinant Human HIPK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HIPK2-4761H Active Recombinant Human HIPK2 Protein, GST-tagged Insect Cell GST
Human HIPK2-4762H Recombinant Human HIPK2 Protein, GST-tagged Wheat Germ GST
Human HIPK2-6604HF Active Recombinant Full Length Human HIPK2 Protein, GST-tagged Insect (sf21) GST 1-1198
Human HIPK2-3534HF Recombinant Full Length Human HIPK2 Protein, GST-tagged In Vitro Cell Free System GST 815 amino acids
Human HIPK2-01H Recombinant Human HIPK2 Protein (1-640), N-Flag-tagged Insect Cell N-Flag 1-640
Human HIPK2-249H Recombinant Human HIPK2 Protein, His-tagged E.coli His Ser977~Ile1198
Human HIPK2-1551HFL Recombinant Full Length Human HIPK2 Protein, C-Flag-tagged Mammalian cells Flag
Human HIPK2-1071H Recombinant Human HIPK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HIPK2-1071H-B Recombinant Human HIPK2 Protein Pre-coupled Magnetic Beads HEK293
Human HIPK2-2212H Recombinant Human HIPK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HIPK2-1130H Recombinant Human HIPK2 Protein (A2-I1198), Tag Free Insect Cell No tag A2-I1198
Human HIPK2-1131H Recombinant Human HIPK2 Protein (A2-I1198), GST tagged Insect Cell GST A2-I1198
Mouse HIPK2-1414M Active Recombinant Mouse HIPK2, GST-tagged Sf9 Insect Cell GST 153-564 aa
Mouse Hipk2-1127M Recombinant Mouse Hipk2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish HIPK2-5797Z Recombinant Zebrafish HIPK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HIPK2 Related Articles

HIPK2 involved in several pathways and played different roles in them. We selected most pathways HIPK2 participated on our site, such as Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt Signaling Pathway NetPathTCF4;MARK2;SALL1;MTAP1B;BRD7;TAX1BP3;CRYBB2;ANKRD6;SOX1

HIPK2 has several biochemical functions, for example, ATP binding, NOT DNA binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK2 itself. We selected most functions HIPK2 had, and list some proteins which have the same functions with HIPK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKCNJ11;STK40;BLK;CLK2;CDK1;FUK;ATP1A1A.2;TRAP1;PLK3
NOT DNA bindingNFIB;TINF2;HIPK2;SKIL;MBD5;XRCC4
RNA polymerase II activating transcription factor bindingBEX1;EGR2;TBX3;EP300;IFI27;SETD3;NHLH2;PITX2;HNF4A
contributes_to RNA polymerase II transcription coactivator activityHIPK2;WWOX
SMAD bindingBMPR1B;SKOR1A;STUB1;YY1;EID2;CREBBP;PML;SKI;HMGA2
kinase activityPHKG1A;IGF1RB;PKDCCA;INSRA;CKMT2B;AGPHD1;NME2A;SRPK1A;PKN2
nucleotide bindingABCA5;NCBP2;PUF60;PL10;RHOT1A;CMPK;CKMB;BAT1;GNA11B
protein bindingNIPA2;KCNIP1;SUMO1;HTR1E;NAV1;ZKSCAN4;AMBRA1;MELK;MRPS31
protein kinase activityEPHA4;CCL5;PAK4;STK24B;ABL2;PKZ;DCLK3;LMTK2;RNASEL
protein serine/threonine kinase activityMYLK4;STK17A;CSNK1DA;LRRK2;SMOK2B;RPS6KA2;RIPK3;PLK1;SIK2A
transcription corepressor activityCSDA;BCOR;RUNX1T1;HOMEZA;ZBTB32;RBFOX2;HOXC6;ZFPM2;SSX2
transferase activityUGT1A5;GGCTB;PFKMA;PKMA;SPTLC3;MOB1BA;PTK2AB;FT1;ACAA1A
virion bindingHIPK2;PVRL1;TSG101;CD209;CLEC4M;PTX3;HSP90B1;APCS;PPIA

HIPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIPK2.

Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
Puca, R; Nardinocchi, L; et al. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. CELL CYCLE 10:1679-1689(2011).
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