Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

HIRA

  • Official Full Name

    histone cell cycle regulator

  • Overview

    This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
  • Synonyms

    HIRA; histone cell cycle regulator; TUP1; DGCR1; TUPLE1; protein HIRA; DiGeorge critical region gene 1; TUP1-like enhancer of split protein 1; HIR histone cell cycle regulation defective homolog A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIRA-4770H Recombinant Human HIRA Protein, GST-tagged Wheat Germ GST
Human HIRA-791HCL Recombinant Human HIRA cell lysate N/A
Human HIRA-3562HF Recombinant Full Length Human HIRA Protein, GST-tagged In Vitro Cell Free System GST 1017 amino acids
Mouse HIRA-7640M Recombinant Mouse HIRA Protein Mammalian Cell His
Mouse HIRA-4171M-B Recombinant Mouse HIRA Protein Pre-coupled Magnetic Beads HEK293
Mouse HIRA-4171M Recombinant Mouse HIRA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HIRA-2084R Recombinant Rhesus monkey HIRA Protein, His-tagged Mammalian Cell His
Rhesus Macaque HIRA-1905R Recombinant Rhesus Macaque HIRA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HIRA-1905R-B Recombinant Rhesus Macaque HIRA Protein Pre-coupled Magnetic Beads HEK293
Chicken HIRA-5805C Recombinant Chicken HIRA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HIRA involved in several pathways and played different roles in them. We selected most pathways HIRA participated on our site, such as Cellular Senescence, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceTERF1;POT1;E2F2;E2F3;BMI1B;HMGA1B;ACD;SUZ12A;RBBP4
Cellular responses to stressCBX8A;PRDX2;WDR45;CBX8;PHC1;MAPKAPK2B;BMI1B;EPAS1B;HIST2H3C
DNA Damage/Telomere Stress Induced SenescenceTERF2;HIST1H1C;ACD;H1F0;UBN1;EP400;HMGA1;HMGA1B;HIRA
Formation of Senescence-Associated Heterochromatin Foci (SAHF)HIST1H1A;HIRA;HMGA1B;HIST1H1D;ASF1A;HIST1H1E;HIST1H1C;CABIN1;UBN1

HIRA has several biochemical functions, for example, protein binding, transcription corepressor activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIRA itself. We selected most functions HIRA had, and list some proteins which have the same functions with HIRA. You can find most of the proteins on our site.

Function Related Protein
protein bindingPEX13;AGR3;MRPL13;RAB6A;USP12;SERPINE1;OLR1;MC1R;JAM2
transcription corepressor activitySSX1;HAND1;ELK3;NFKBIL2;ATF7IP;MYBBP1A;BASP1;CRYM;HDAC3
transcription factor activity, sequence-specific DNA bindingBHLHE22;NEUROD2;GATA2B;ATF7;IRF1A;MKL1;TBPL2;ZNF643;SOX13

HIRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HIRA.

H3F3A; Whsc1; UPF1; AIM2; PTBP3; MYC; SNW1; PYHIN1; CDC5L; Cdc26; ASF1A

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HIRA Products

Required fields are marked with *

My Review for All HIRA Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends