Recombinant Human HIRA Protein, GST-tagged

• Cat.No.: HIRA-4770H
• Product Overview: Human HIRA full-length ORF ( NP_003316.3, 1 a.a. - 1017 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 138.2 kDa
• AA Sequence: MKLLKPTWVNHNGKPIFSVDIHPDG TKFATGGQGQDSGKVVIWNMSPVLQ EDDEKDENIPKMLCQMDNHLACVNC VRWSNSGMYLASGGDDKLIMVWKRA TYIGPSTVFGSSGKLANVEQWRCVS ILRNHSGDVMDVAWSPHDAWLASCS VDNTVVIWNAVKFPEILATLRGHSG LVKGLTWDPVGKYIASQADDRSLKV WRTLDWQLETSITKPFDECGGTTHV LRLSWSPDGHYLVSAHAMNNSGPTA QIIEREGWKTNMDFVGHRKAVTVVK FNPKIFKKKQKNGSSAKPSCPYCCC AVGSKDRSLSVWLTCLKRPLVVIHE LFDKSIMDISWTLNGLGILVCSMDG SVAFLDFSQDELGDPLSEEEKSRIH QSTYGKSLAIMTEAQLSTAVIENPE MLKYQRRQQQQQLDQKSAATREMGS ATSVAGVVNGESLEDIRKNLLKKQV ETRTADGRRRITPLCIAQLDTGDFS TAFFNSIPLSGSLAGTMLSSHSSPQ LLPLDSSTPNSFGASKPCTEPVVAA SARPAGDSVNKDSMNATSTPAALSP SVLTTPSKIEPMKAFDSRFTERSKA TPGAPALTSMTPTAVERLKEQNLVK ELRPRDLLESSSDSDEKVPLAKASS LSKRKLELEVETVEKKKKGRPRKDS RLMPVSLSVQSPAALTAEKEAMCLS APALALKLPIPSPQRAFTLQVSSDP SMYIEVENEVTVVGGVKLSRLKCNR EGKEWETVLTSRILTAAGSCDVVCV ACEKRMLSVFSTCGRRLLSPILLPS PISTLHCTGSYVMALTAAATLSVWD VHRQVVVVKEESLHSILAGSDMTVS QILLTQHGIPVMNLSDGKAYCFNPS LSTWNLVSDKQDSLAQCADFRSSLP SQDAMLCSGPLAIIQGRTSNSGRQA ARLFSVPHVVQQETTLAYLENQVAA ALTLQSSHEYRHWLLVYARYLVNEG FEYRLREICKDLLGPVHYSTGSQWE STVVGLRKRELLKELLPVIGQNLRF QRLFTECQEQLDILRDK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HIRA HIR histone cell cycle regulation defective homolog A (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: HIRA
• Synonyms: HIRA; HIR histone cell cycle regulation defective homolog A (S. cerevisiae); HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae) , TUPLE1; protein HIRA; DGCR1; DiGeorge critical region gene 1; TUP1; TUP1-like enhancer of split protein 1; TUPLE1
• Gene ID: 7290
• mRNA Refseq: NM_003325
• Protein Refseq: NP_003316
• MIM: 600237
• UniProt ID: P54198