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HLCS

  • Official Full Name

    holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

  • Overview

    This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    HLCS; holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin (proprionyl Coenzyme A carboxylase (ATP hydrolysing)) ligase) , holocarboxylase synthetase (biotin [proprionyl Coenzyme A carboxylase (ATP hydrolysing)] ligase); biotin--protein ligase; HCS; Biotin [acetyl CoA carboxylase] ligase; Biotin [methylcrotonoyl CoA carboxylase] ligase; Biotin [methylmalonyl CoA carboxytransferase] ligase; Biotin [propionyl CoA carboxylase [ATP hydrolyzing]] ligase; Biotin apo protein ligase; Biotin apo-protein ligase; Biotin protein ligase; Biotin--[acetyl-CoA-carboxylase] ligase; BPL1_HUMAN; EC 6.3.4.-; Holocarboxylase synthetase; Holocarboxylase synthetase, EC 6.3.4; biotin--[methylcrotonoyl-CoA-carboxylase] ligase; biotin--[methylmalonyl-CoA-carboxytransferase] ligase; holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLCS-4850H Recombinant Human HLCS Protein, GST-tagged Wheat Germ GST
Human HLCS-5491HCL Recombinant Human HLCS 293 Cell Lysate HEK293 N/A
Human HLCS-6636H Recombinant Human HLCS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HLCS-3632HF Recombinant Full Length Human HLCS Protein, GST-tagged In Vitro Cell Free System GST 726 amino acids
Human HLCS-2244H Recombinant Human HLCS Protein, His-tagged E.coli N-His Met1-Ser172
Mouse Hlcs-491M Recombinant Mouse Hlcs Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLCS Related Articles

HLCS involved in several pathways and played different roles in them. We selected most pathways HLCS participated on our site, such as Biotin metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biotin metabolismBTD;OXSM;HLCS
Metabolic pathwaysMGAT2;ACSL3B;LPIN3;BAAT;CYP19A1;MTMR1A;MAN1A;CYP11C1;PANK4

HLCS has several biochemical functions, for example, ATP binding, biotin binding, biotin-[acetyl-CoA-carboxylase] ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLCS itself. We selected most functions HLCS had, and list some proteins which have the same functions with HLCS. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIK3C2B;MAPK15;PRKCQ;FGFR4;ROS1;MAP2K1;DHX16;ATP1A4;PPP1CA
biotin bindingMCCC1;AVR2;PCXA;PC;PCXB;HLCS;PCCA
biotin-[acetyl-CoA-carboxylase] ligase activity
biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
biotin-protein ligase activity
enzyme bindingCYP3A4;PEBP1;ANK1;SPDL1;NPM2;APOA1;PDE4D;PRTN3;HYAL2
protein bindingCRHR2;RTN4;DRG1;ARHGAP33;BUD31;AFF4;MYOG;PTGES2;NUP35
protein homodimerization activityTrl;TYR;SMAD3;CHMP4B;ACAT1;MASP1;AGXT;TERF2;BCL11A

HLCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLCS here. Most of them are supplied by our site. Hope this information will be useful for your research of HLCS.

ACACB; POT1; SNX27; DDX52

Vosough, M; Omidinia, E; et al. Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture. STEM CELLS AND DEVELOPMENT 22:2693-2705(2013).
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