hnrnph2
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  • Official Full Name
  • heterogeneous nuclear ribonucleoprotein H2 (H)
  • Background
  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed.
  • Synonyms
  • HNRNPH2; heterogeneous nuclear ribonucleoprotein H2 (H); HNRPH2; heterogeneous nuclear ribonucleoprotein H2; FTP3; hnRNPH; HNRPH; FTP-3; hnRNP H; hnRNP H2; heterogeneous nuclear ribonucleoprotein H-prime
Cat.#:HNRNPH2-4903HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HNRNPH2 Protein, GST-tagged
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Cat.#:HNRNPH2-424HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HNRNPH2
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Cat.#:HNRNPH2-2883RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HNRNPH2 Protein
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Cat.#:HNRNPH2-2124RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HNRNPH2 Protein, His-tagged
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Cat.#:HNRNPH2-5445HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNRNPH2 293 Cell Lysate
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Involved Pathway

HNRNPH2 involved in several pathways and played different roles in them. We selected most pathways HNRNPH2 participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPH2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
TCEB3; ZNF221; ZNF554; NR5A1B; ZFP90; NR1I3; TBX5A; QTRTD1; RNPS1; ZNF75A
Processing of Capped Intron-Containing Pre-mRNA
SLBP; HNRNPL2; RNPS1; ZCRB1; PTBP1; U2AF2; TXNL4A; PTBP1B; RBM5; SF3A1
mRNA Splicing
PCBP2; HNRNPH1; HNRNPD; CCAR1; DNAJC8; PDCD7; HNRNPH1L; HNRPL; PTBP1A; TTC6
mRNA Splicing - Major Pathway
SF3A3; HNRNPR; HNRNPA2B1; HNRNPL; HNRNPH2; CCAR1; DNAJC8; HNRNPL2; SUGP1; HNRNPF
mRNA processing
ADARB2; CELF4; BICC1; ZFP740; PTBP2; LSMD1; HNRNPH2; HNRPL; SFPQ; OASL2

Protein Function

HNRNPH2 has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPH2 itself. We selected most functions HNRNPH2 had, and list some proteins which have the same functions with HNRNPH2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein ALYREF; EXOSC3; NPM1; THOC6; CELF3; HNRNPH1; BRCA1; NIFK; PDCD4; BARHL1
Function nucleotide binding
Related Protein RBM4; ATP1A1A.2; ARL4CA; RBM11; SRSF7; PL10; ATP9B; VDAC2; TUBA8L4; NME2B.1
Function poly(A) RNA binding
Related Protein HSP90AB1; DARS; NOC2L; RBM4; SRSF12; HDAC2; MSI1; DCN; RPS17; NOP58
Function protein binding
Related Protein KANK2; LNX2B; DERL3; TJP2; TRIP12; RHNO1; DCSTAMP; ZMYM5; PFKL; MAPK8IP3

Interacting Protein

HNRNPH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPH2.
TEKT1; MSI2; HNRNPA0; Ybx1; YWHAZ; RBFOX2; PQBP1; HSPB1; SNRPC; DDX5; GNB2L1; RBM10; ILF3; RBM39