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HNRNPL

  • Official Full Name

    heterogeneous nuclear ribonucleoprotein L

  • Overview

    Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    HNRNPL; heterogeneous nuclear ribonucleoprotein L; HNRPL; hnRNP-L; P/OKcl.14; hnRNP L;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNRNPL-4905H Recombinant Human HNRNPL Protein, GST-tagged Wheat Germ GST
Human HNRNPL-5441HCL Recombinant Human HNRNPL 293 Cell Lysate HEK293 N/A
Human HNRNPL-3616HF Recombinant Full Length Human HNRNPL Protein, GST-tagged In Vitro Cell Free System GST 558 amino acids
Human HNRNPL-559H Recombinant Human HNRNPL Protein (1-589 aa), His-SUMO-tagged E.coli His/SUMO 1-589 aa
Human HNRNPL-1414H Recombinant Human HNRNPL Protein (89-335 aa), His-tagged Yeast His 89-335 aa
Human HNRNPL-558H Recombinant Human HNRNPL Protein (89-335 aa), His-SUMO-tagged E.coli His/SUMO 89-335 aa
Rhesus Macaque HNRNPL-2127R Recombinant Rhesus monkey HNRNPL Protein, His-tagged Mammalian Cell His
Rhesus Macaque HNRNPL-1948R Recombinant Rhesus Macaque HNRNPL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HNRNPL-1948R-B Recombinant Rhesus Macaque HNRNPL Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HNRNPL Related Articles

HNRNPL involved in several pathways and played different roles in them. We selected most pathways HNRNPL participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionTXN;NR6A1;MED10;MED25;PSTPIP2;NR2C2;HNRPL;EFCAB11;SSRP1A
Processing of Capped Intron-Containing Pre-mRNAHNRPL;METTL14;HNRNPUL1;NUDT21;SF3A1;CSTF3;METTL3;CSTF2;RBM5
mRNA SplicingPRPF8;ZMAT5;DNAJC8;HNRNPA0;HNRNPA0A;HNRNPF;SF3B4;HNRNPD;PTBP1B
mRNA Splicing - Major PathwayHNRNPD;SFRS3A;PRPF8;PTBP1A;RBM5;HNRPL;HNRNPA0B;HNRNPH1;HNRNPR
mRNA processingCELF4;FAM120B;RBMS3;SFSWAP;D19BWG1357E;RBM4B;RPL36A-HNRNPH2;HNRNPD;PRPF4BB

HNRNPL has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPL itself. We selected most functions HNRNPL had, and list some proteins which have the same functions with HNRNPL. You can find most of the proteins on our site.

Function Related Protein
RNA bindingAGO1;RAVER2;RAE1;TDRKH;IREB2;HNRNPUL1;CPSF2;EWSR1;CPSF5
nucleotide bindingDND1;PSMC1A;HNRNPH2;ARF1L;HSP90AA1.1;D19ERTD386E;MAPK8B;ABCC8;CIRBP
poly(A) RNA bindingRPP25L;SUB1;SRSF7;RPL32;LRPPRC;NCBP2;CKAP4;MRPS15;HSPA8
protein bindingTCAP;PTGDS;IL33;MBNL1;TMED5;KLF12;ZNF496;ASB13;CD3E
transcription regulatory region DNA bindingNR1H3;XRCC5;BCL11B;ZFP513;ZNF335;KLF11;IKZF1;TFAP4;ARID5B

HNRNPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPL here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPL.

YBX1; CSNK2A1; 4505953; SGK1; DFFA; CFLAR; SSSCA1; RARA; YWHAZ; ILK; EIF2B1; DOCK4; TNFRSF14; ZNF143; TMBIM4; SMYD2; PUF60; TRAF6

Yoneyama, K; Kojima, S; et al. Proteomic Identification of Autoantibodies in Sera from Patients with Ovarian Cancer as Possible Diagnostic Biomarkers. ANTICANCER RESEARCH 35:881-889(2015).
Lee, DH; Lim, MH; et al. hnRNP L binds to CA repeats in the 3 ' UTR of bcl-2 mRNA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 382:583-587(2009).
Huang, S; et al. Perinucleolar structures. JOURNAL OF STRUCTURAL BIOLOGY 129:233-240(2000).
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