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HSPG2

  • Official Full Name

    heparan sulfate proteoglycan 2

  • Overview

    PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four PLC family members have been identified: PLCbeta, PLCgamma, PLCDelta, and PLCEpsilon. In response to extracellular stimuli (e.g., hormone, growth fac
  • Synonyms

    HSPG2; heparan sulfate proteoglycan 2; Schwartz Jampel syndrome 1 (chondrodystrophic myotonia) , SJS1; basement membrane-specific heparan sulfate proteoglycan core protein; perlecan; perlecan proteoglycan; PRCAN; endorepellin (domain V region); PLC; SJA;

  • Recombinant Proteins
  • Chicken
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • NS0
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPG2-01H Active Recombinant Human HSPG2 protein, His-tagged NS0 His
Human HSPG2-29309TH Recombinant Human HSPG2 Wheat Germ N/A 110 amino acids
Human HSPG2-8046H Recombinant Human HSPG2 protein, His-tagged E.coli His Leu4149~Ser4391
Human HSPG2-5262H Recombinant Human HSPG2 Protein, GST-tagged Wheat Germ GST
Human HSPG2-2230H Recombinant Human HSPG2 protein, His&Myc-tagged Insect Cell His&Myc 4197-4391aa
Human HSPG2-03H Recombinant Human HSPG2 Protein, His-Tagged E.coli His
Human HSPG2-5026H Recombinant Human HSPG2 protein, His&Myc-tagged HEK293 His&Myc 4197-4391aa
Human HSPG2-05HCL Recombinant Human HSPG2 Over-expression Lysate, C-Myc/DDK tagged HEK293T C-Myc/DDK
Mouse HSPG2-02M Active Recombinant Mouse HSPG2 protein, His-tagged CHO His
Chicken HSPG2-1178C Recombinant Chicken HSPG2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPG2 Related Articles
  • HSPG2 Related Signal Pathway

HSPG2 involved in several pathways and played different roles in them. We selected most pathways HSPG2 participated on our site, such as ECM-receptor interaction, Hepatitis B, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionCOL6A1;COL2A1;COL3A1;COL5A1;SV2C;LAMC2;VTNB;COL27A1A;ITGB7
Hepatitis BNFATC3;IFNAR1;NFKBIA;ATF4;PIK3CG;NFATC1;IFNA16;IFNB1;TGFB3
Proteoglycans in cancerPPP1CC;THBS1;PTPN6;GRB2;ESR1;ITGB1;ANK2;WNT8A;MAPK1

HSPG2 has several biochemical functions, for example, metal ion binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPG2 itself. We selected most functions HSPG2 had, and list some proteins which have the same functions with HSPG2. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingPLA2G2F;ZFP319;CYP2P7;ZNF277;HDHD2;TROVE2;ZNF582;CYP1C2;ZFP628
protein C-terminus bindingSNX17;VPS4B;JAK2;PPP2CB;CEP120;KCNK3;TFCP2;RABAC1;STIP1
protein bindingSNX20;ELMO3;MUC2;RCC2;EEF1A2;TPRKB;IGF2R;SIGIRR;DCDC2

HSPG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPG2.

KDR; GRN; FLT1; Npnt; FGF1; FGF2; FGFR1; FGFR3; CACNA1A; TCAP; ATN1

Hayes, AJ; Gibson, MA; et al. Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. TISSUE & CELL 46:185-197(2014).
Brown, AJ; Alicknavitch, M; et al. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. BONE 43:689-699(2008).
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