hyal2
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  • Official Full Name
  • hyaluronoglucosaminidase 2
  • Background
  • This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5 UTR.[provided by RefSeq, Mar 2010]
  • Synonyms
  • HYAL2; hyaluronoglucosaminidase 2; LUCA2; hyaluronidase-2; hyal-2; PH20 homolog; PH-20 homolog; hyaluronidase 2; lysosomal hyaluronidase; lung carcinoma protein 2; hyaluronoglucosaminidase-2;
Cat.#:HYAL2-5221HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HYAL2 Protein, GST-tagged
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Cat.#:HYAL2-14019HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HYAL2, His-tagged
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Cat.#:Hyal2-1172MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hyal2 protein, His-tagged
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Cat.#:HYAL2-7953MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HYAL2 Protein
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Cat.#:HYAL2-2180RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HYAL2 Protein, His-tagged
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Cat.#:HYAL2-5323HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HYAL2 293 Cell Lysate
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Involved Pathway

HYAL2 involved in several pathways and played different roles in them. We selected most pathways HYAL2 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
IDS; HYAL2; SGSH; GALNS; HGSNAT; HPSE; GNSB; HYAL6; HEXA; HEXB
Metabolic pathways
DHCR24; ALDOC; ATP6V0A1; DSE; MAT2AA; GLS2; POLR3G; C1GALT1C1; CYP2B6; IDO2

Protein Function

HYAL2 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, enzyme binding, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL2 itself. We selected most functions HYAL2 had, and list some proteins which have the same functions with HYAL2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription coactivator activity
Related Protein PITX2; RERE; CREBBP; WBP2; TRIM28; POU3F1; SMARCA4; PRRX1; MKL1B; MKL1
Function enzyme binding
Related Protein PEX7; TNKS2; HINFP; DVL1; MARCH6; PTPLAD1; CBX3; ATXN10; KRT79; KDM4C
Function hyaluronic acid binding
Related Protein HAPLN1A; NCAN; HAPLN3; HYAL2; C1QBP; IMPG2; BCAN; VCAN; LAYN; CD44
Function hyaluronoglucuronidase activity
Related Protein HYAL3; HYAL2
Function hyalurononglucosaminidase activity
Related Protein HYAL3; MGEA5; HYAL6; HYAL2; KIAA1199; CD44; SPAM1; HYAL4; HYAL1
Function NOT hyalurononglucosaminidase activity
Related Protein HYAL1; HYAL3; HYAL2
Function protein binding
Related Protein LGALS14; NEDD4L; MYEF2; DSTN; PHOSPHO2; SPERT; GLI2; SSBP3; S100P; TMPRSS15
Function receptor signaling protein tyrosine kinase inhibitor activity
Related Protein HYAL2
Function receptor tyrosine kinase binding
Related Protein GAS6; ELMO2; NCK1; FNTA; PTPN2; MYOC; TOB1; DOCK4; SOCS5; LRP4
Function transforming growth factor beta binding
Related Protein HYAL2; TGFBR2; THBS1; LTBP1; ITGAV; ENG; ACVR1; TGFBR3; ACVRL1; LTBP4
Function virus receptor activity
Related Protein SELPLG; IDE; MRC1; F11R; ICAM1; CLDN1; HAVCR1; CXADR; SLC20A2; HYAL2

Interacting Protein

HYAL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL2.
FHL3; KRTAP3-2; fadE; q5nii2_fratt; pepP; yqgS

HYAL2 Related Articles

Marei, WFA; Salavati, M; et al. Critical role of hyaluronidase-2 during preimplantation embryo development. MOLECULAR HUMAN REPRODUCTION 19:590-599(2013).
Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
Li, LL; Asteriou, T; et al. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. BIOCHEMICAL JOURNAL 404:327-336(2007).
Selbi, W; de la Motte, C; et al. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. KIDNEY INTERNATIONAL 70:1287-1295(2006).