jag2
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  • Official Full Name
  • jagged 2
  • Background
  • The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • JAG2; jagged 2; protein jagged-2; HJ2; SER2
Cat.#:JAG2-1869HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human JAG2 protein, His-tagged
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Cat.#:JAG2-229HTag:Fc Chimera
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human JAG2, Fc Chimera
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Cat.#:JAG2-29877THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human JAG2
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Cat.#:JAG2-382HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human JAG2, Fc-tagged
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Cat.#:JAG2-601HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human JAG2
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Cat.#:Jag2-1870MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Jag2 protein, His & T7-tagged
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Cat.#:Jag2-383MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Jag2, Fc-tagged
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Cat.#:Jag2-5666MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Jagged 2, Fc-tagged
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Cat.#:JAG2-8407MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse JAG2 Protein
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Involved Pathway

JAG2 involved in several pathways and played different roles in them. We selected most pathways JAG2 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAG2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated NOTCH1 Transmits Signal to the Nucleus
ADAM10; DNER; DLK1; CNTN1; JAG2; JAG1; MIB1; DTX2
Constitutive Signaling by NOTCH1 HD Domain Mutants
JAG1; JAG2; MIB1; ADAM10
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDAC5; ADAM10; JAG1; CDK8; HEY1; HEYL; CCNC; MIB1; HDAC6; HEY2
Constitutive Signaling by NOTCH1 PEST Domain Mutants
HEYL; MIB1; CCNC; JAG2; JAG1; HEY1; CDK8; HEY2; ADAM10; HDAC6
Constitutive Signaling by NOTCH1 t(7
JAG2; JAG1
9)(NOTCH1:M1580_K2555) Translocation Mutant
JAG1; JAG2
Delta-Notch Signaling Pathway
ASCL1A; HES6; CNTN1B; CNTN1; RING1; HEY1; MAGEA1; NOV; YY1; YY1A
Disease
ARF1; PRELP; TNKS; LRRFIP1; TNKS2; HEY2; TCEB3; FGFR1OP; CPSF6; HEYL
Diseases of signal transduction
KREMEN2; OPN1SW; CUX1; LRRFIP1; OPN1MW; OPN1LW; CTBP2; CDC37; OPN1MW2; CPSF6

Protein Function

JAG2 has several biochemical functions, for example, Notch binding, calcium ion binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAG2 itself. We selected most functions JAG2 had, and list some proteins which have the same functions with JAG2. You can find most of the proteins on our site.
Function
Related Protein
Function Notch binding
Related Protein CHAC1; DLL1; JAG1A; DTX1; SNW1; EGFL7; AAK1; NOTCH4; NOV; NCOR2
Function calcium ion binding
Related Protein PCDH2G5; PLSCR3; MICU2; SPATA21; CAPN2B; SLC25A25; DAG1; MAN1A1; ANXA1A; PLSCR2
Function growth factor activity
Related Protein FGF1B; BMP6; BMP2B; ENDOU; PSPN; AREG; NOV; Fgf15; JAG2; BDNF
Function protein binding
Related Protein FOXP2; FZD2; ACO1; BRD3; KCNE4; UPK3A; MKNK1; TRPC6; TMEM25; CHMP5

Interacting Protein

JAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAG2.
GFI1B; CACNA1A; ATXN7; ATN1; thrS2; q81wx2_bacan; q9wmx2-pro_0000037548