Recombinant Human JAG2, Fc-tagged

• Cat.No.: JAG2-382H
• Product Overview: Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 1-1054 a.a.
• Description: Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappa;B and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
• Form: Liquid. 0.2μm-filtered solution in PBS.
• Molecular Mass: ~150kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Concentration: 0.2mg/ml

Gene Information

• Gene Name: JAG2 jagged 2 [ Homo sapiens ]
• Official Symbol: JAG2
• Synonyms: JAG2; jagged 2; protein jagged-2; HJ2; SER2
• Gene ID: 3714
• mRNA Refseq: NM_002226
• Protein Refseq: NP_002217
• MIM: 602570
• UniProt ID: Q9Y219
• Chromosome Location: 14q32
• Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem
• Function: Notch binding; calcium ion binding; growth factor activity; protein binding