KDELR2
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Official Full Name
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
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Overview
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
KDELR2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ER lumen protein retaining receptor 2; ELP 1; ERD2.2; (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; ELP1; ERD 2 like protein; ERD2 like protein 1; FLJ45532; KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR 2; ERD-2-like protein; ERD2-like protein 1; (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ELP-1;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Xenopus laevis (African clawed frog)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
KDELR2 involved in several pathways and played different roles in them. We selected most pathways KDELR2 participated on our site, such as Vibrio cholerae infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vibrio cholerae infection | TJP2;ATP6AP1;ATP6V1E2;ATP6V0D2;ATP6V0A1;KDELR1;PLCG1;ACTG1;PRKACG |
KDELR2 has several biochemical functions, for example, KDEL sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR2 itself. We selected most functions KDELR2 had, and list some proteins which have the same functions with KDELR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| KDEL sequence binding | KDELR1;KDELR2 |
KDELR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDELR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KDELR2.
PARP2; SERINC3; ERBB2; P
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