kpna4
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  • Official Full Name
  • karyopherin alpha 4 (importin alpha 3)
  • Background
  • The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
  • Synonyms
  • KPNA4; karyopherin alpha 4 (importin alpha 3); importin subunit alpha-4; IPOA3; MGC12217; MGC26703; QIP1; SRP3; importin alpha Q1; karyopherin subunit alpha-4; FLJ31113
Cat.#:KPNA4-29909THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KPNA4 Protein, GST-tagged
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Cat.#:KPNA4-8800MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KPNA4 Protein
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Cat.#:KPNA4-1811CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KPNA4
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Cat.#:KPNA4-11453ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KPNA4
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Cat.#:KPNA4-4889HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KPNA4 293 Cell Lysate
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Involved Pathway

KPNA4 involved in several pathways and played different roles in them. We selected most pathways KPNA4 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes
DPF1; ARIH1L; EIF4G1; JAK1; UBE2L6; EIF4E3; EIF4G2A; KPNA4; NUPL2; IFIT10
Cytokine Signaling in Immune system
IFI6; KPNA3; TRIM14; EIF4A1; CISH; HERC5; TRIM10; IFIT3; IL17RD; PAQR3B
Disease
STRA6; PDCD6IP; RBP1; FGFR1OP2; COBRA1; FDX1L; PSTPIP2; OGN; CTDP1; CYP11A1
Host Interactions with Influenza Factors
KPNA4; KPNA3; KPNA5; CPSF4
ISG15 antiviral mechanism
IFIT10; IFIT8; MX2; IFIT14; IFIT11; UBE2L6; KPNA3; IFIT12; ARIH1; EIF4G2A
Immune System
CTSB; ISG20; MICA; AP1G1; ASB4; OSCAR; IFI16; SIGLEC10; TRIM6; DEFB104A
Infectious disease
AP1G1; ANTXR1; PDCD6IP; KPNA4; EEF2; CHMP4B; KPNA5; VPS37A; PACS1; NMT1
Influenza Infection
CPSF4; KPNA5; KPNA4; IPO5; KPNA3

Protein Function

KPNA4 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA4 itself. We selected most functions KPNA4 had, and list some proteins which have the same functions with KPNA4. You can find most of the proteins on our site.
Function
Related Protein
Function nuclear localization sequence binding
Related Protein KPNA3; IPO13; KPNA6; IPO4; RANBP6; KPNA2; KPNA1; IPO5; BRAP; NUP214
Function protein binding
Related Protein BRPF3; RND2; EIF5A; ACAA2; HIST1H3D; TBC1D22B; UQCC2; GALR2; CSF3R; STOML1
Function protein transporter activity
Related Protein FRAG1; ITGB1BP1; L7RN6; AP2S1; KPNA2; AP2B1; KPNA6; AP1S3A; RAMP3; TNPO2

Interacting Protein

KPNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA4.
gag-pol; HNRNPC; CYHR1; Ranbp2; MAT2B; NUP50; PLAA

KPNA4 Related Articles

Arjomand, A; Baker, MA; et al. The alpha-importome of mammalian germ cell maturation provides novel insights for importin biology. FASEB JOURNAL 28:3480-3493(2014).
Whiley, PAF; Miyamoto, Y; et al. Changing subcellular localization of nuclear transport factors during human spermatogenesis. INTERNATIONAL JOURNAL OF ANDROLOGY 35:158-169(2012).