MALT1
-
Official Full Name
mucosa associated lymphoid tissue lymphoma translocation gene 1
-
Overview
MALT-1 was independently identified as a member of the human paracaspase family and an interacting partner of B cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT-1 gene. Human MALT isoform a is an amino acid protein of 824 amino acids, and human MALT-2 isoform b is an amino acid protein of 813 amino acids. MALT-1 is thought to play a role in NFkappaB signaling by enchancing NF kappaB activation through interaction with BCL-10. Interaction between MALT-1 and BCL-10 mediates IKK activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13. -
Synonyms
MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|Thioredoxin
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- MALT1 Related Articles
- MALT1 Related Research Area
MALT1 involved in several pathways and played different roles in them. We selected most pathways MALT1 participated on our site, such as Activation of NF-kappaB in B cells, Adaptive Immune System, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MALT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of NF-kappaB in B cells | CHUK;MALT1 |
| Adaptive Immune System | CD96;TRIM50;UBE2J2;MKRN1;UBE2V2;VPRBP;AKT3;MAP3K8;KIF15 |
| B cell receptor signaling pathway | BANK1;CD79B;MAPK4;SLA2;CDK6;IFITM1;BLNK;ACTR2;CARD11 |
| BCR signaling pathway | NETO2;CSNK2A1;MAP4K1;MALT1;POU2F2;CSK;IBTK;PAG1;DOK1 |
| C-type lectin receptors (CLRs) | CLEC6A;CLEC4A;ITPR2;IL1B2;CASP8L1;CLEC4D;MALT1;TAB1;AHCYL1 |
| CLEC7A (Dectin-1) signaling | TAB1;MALT1;AHCYL1;IL1B2;UBE2V1;CASP8L1 |
| CLEC7A/inflammasome pathway | MALT1;CASP8L1;IL1B2 |
| Canonical NF-kappaB pathway | MALT1;CYLD |
MALT1 has several biochemical functions, for example, cysteine-type endopeptidase activity, contributes_to kinase activator activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MALT1 itself. We selected most functions MALT1 had, and list some proteins which have the same functions with MALT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | Ctsl;CASP6L1;CASP14;USP24;CASPB;USP17L5;BLMH;CTSO;USP51 |
| contributes_to kinase activator activity | MALT1;BCL10 |
| peptidase activity | ELA2L;CASP8;FURINA;CTSJ;PROCA;PLAUB;CPD;PCSK5B;KLK1B3 |
| protease binding | PYCARD;SERPINE1;SERPINB9;BRCA2;SERPINB13;ELANE;VWF;CSTA;CNTNAP2 |
| protein binding | SAP30;VCP;PID1;NANOS3;MTCH1;ATG4A;TMEM132D;FAM9A;TYR |
| protein self-association | PABPN1;TNFAIP3;L1CAM;CBR2;PCSK9;ACHE;MDH2;NKX3-1;SVIP |
| signal transducer activity | GNB1;CD24;OLFR481;GULP1;PLCB3;GNAI3;OLFCG5;TMTOPS3B;OLFR11 |
| ubiquitin-protein transferase activity | RNF5;TRAF6;SIAH1A;RNF125;RLIM;UBE2D2A;FBXL14B;TRIM27;SHPRH |
MALT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MALT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MALT1.
BCL10; UBC; SQSTM1; IKBKG
- Q&As
- Reviews
Q&As (5)
Ask a questionMALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.
Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.
Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.
Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.
MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.
Customer Reviews (3)
Write a reviewFrom recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.
the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.
the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.
Ask a Question for All MALT1 Products
Required fields are marked with *
My Review for All MALT1 Products
Required fields are marked with *
