MALT1

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MALT1

Official Full Name mucosa associated lymphoid tissue lymphoma translocation gene 1
Background MALT-1 was independently identified as a member of the human paracaspase family and an interacting partner of B cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT-1 gene. Human MALT isoform a is an amino acid protein of 824 amino acids, and human MALT-2 isoform b is an amino acid protein of 813 amino acids. MALT-1 is thought to play a role in NFkappaB signaling by enchancing NF kappaB activation through interaction with BCL-10. Interaction between MALT-1 and BCL-10 mediates IKK activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13.
Synonyms MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Thioredoxin
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Malt1-14HCL Recombinant Mouse Malt1 overexpression lysate HEK293T Myc/DDK
    Human MALT1-234H Recombinant Human MALT1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MALT1-2551H Recombinant Human MALT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Malt1-26HCL Recombinant Mouse Malt1 overexpression lysate HEK293T Myc/DDK
    Mouse Malt1-3911M Recombinant Mouse Malt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MALT1-27H Recombinant Human MALT1, GST-tagged Wheat Germ GST
    Human MALT1-28H Recombinant Human MALT1, MYC/DDK-tagged HEK293 Myc/DDK
    Human MALT1-4527HCL Recombinant Human MALT1 293 Cell Lysate HEK293 N/A
    Human MALT1-717H Recombinant Human MALT1, GST-tagged E.coli GST
    Human MALT1-857H Recombinant Human MALT1 protein, His/Thioredoxin-tagged E.coli His/Thioredoxin
    Mouse MALT1-9472M Recombinant Mouse MALT1 Protein Mammalian Cell His

    MALT1 involved in several pathways and played different roles in them. We selected most pathways MALT1 participated on our site, such as Activation of NF-kappaB in B cells, Adaptive Immune System, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MALT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of NF-kappaB in B cells CHUK; MALT1
    Adaptive Immune System CD200R2; ASB3; EGFR; CD300LD; PJA1; UBA5; THEM4; CTSE; B2ML; CTSLL
    B cell receptor signaling pathway ACTR3; BANK1; PLEKHA2; STAP1; LCP2A; CD81; ARPC4; CRKL; NFKBIB; GSK3AB
    BCR signaling pathway PAG1; MALT1; IBTK; NETO2; DOK1; POU2F2; CSK; MAP4K1; CSNK2A1
    C-type lectin receptors (CLRs) TAB1; MALT1; IL1B2; ITPR2; CLEC4D; CLEC6A; CREBBP; CASP8L1; AHCYL1; CLEC4A
    CLEC7A (Dectin-1) signaling MALT1; CASP8L1; TAB1; UBE2V1; IL1B2; AHCYL1
    CLEC7A/inflammasome pathway MALT1; CASP8L1; IL1B2
    Canonical NF-kappaB pathway MALT1; CYLD

    MALT1 has several biochemical functions, for example, cysteine-type endopeptidase activity, contributes_to kinase activator activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MALT1 itself. We selected most functions MALT1 had, and list some proteins which have the same functions with MALT1. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity USP12A; CFLARA; CASP6L1; USP9; USP24; USP47; SFRP1; FAM49BA; CTSLL; USP42
    contributes_to kinase activator activity BCL10; MALT1
    peptidase activity KLK1B24; CAPN5A; MALT1; CTSM; PRSS41; PROCA; CASPBL; SPCS3; PLAUB; MMP25
    protease binding CFLAR; TIMP2; C10orf2; SERPINB6; CD70; MALT1; ADAMTSL4; SEMG2; LDLR; PEO1
    protein binding COL17A1; TRIB3; TRAM2; RAD54L; ARRB1; FH; TAF1D; MXD3; TNP1; ZEB1
    protein self-association RYR2; RSAD2; PTH1R; TRP53; NKX3-1; CTSB; TMEM190; MDH2; PABPN1; ZKSCAN17
    signal transducer activity SLC20A1; VMN1R47; TAS2R107; PPP1R12A; STAT5A; SLC44A2; AVP; GNAI3; TAAR13E; OLFR958
    ubiquitin-protein transferase activity BRCA1; TRIM71; UBE2A; RNF151; PRP19; MARCH5; RNF220; DTX3L; MUL1; TRIM56

    MALT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MALT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MALT1.

    BCL10; UBC; SQSTM1; IKBKG

    Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
    Chinen, J; Notarangelo, LD; et al. Advances in basic and clinical immunology in 2013. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133:967-976(2014).

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