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Recombinant Mouse Malt1 overexpression lysate

Cat.No. : Malt1-26HCL
Product Overview : Transient overexpression lysate of Mouse mucosa associated lymphoid tissue lymphoma translocation gene 1 (Malt1) with a C-Myc/DDK tag was expressed in HEK293T.
Preparation: HEK293T cells in 10-cm dishes were transiently transfected. Transfected cells were cultured for 48hrs before collection. The cells were lysed in modified RIPA buffer (25mM Tris-HCl pH7.6, 150mM NaCl, 1% NP-40, 1mM EDTA, 1xProteinase inhibitor cocktail mix, 1mM PMSF and 1mM Na3VO4), and then centrifuged to clarify the lysate. Protein concentration was measured by BCA kit. Cell lysates were aliquoted and stored at -20 centigrade before shipping.
Components:
1 vial of 100 μg gene specific transient over-expression cell lysate in RIPA buffer
1 vial of 100 μg empty vector transfected control cell lysate in RIPA buffer
1 vial of 250 μL 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT)
  • Specification
  • Gene Information
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Description : Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 92.5 kDa
Stability : Avoid repeated freeze-thaw cycles. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade.
Storage : Upon receiving, store the sample at -20 centigrade.
Reconstitution : Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage.
Shipping : The lysate is shipped with dry ice.
Gene Name : Malt1 MALT1 paracaspase [ Mus musculus (house mouse) ]
Official Symbol : Malt1
Synonyms : Malt1; MALT1 paracaspase; Pc; pa; Pcasp1; A630046N12; D430033E09Rik; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Names; mucosa associated lymphoid tissue lymphoma translocation gene 1; paracaspase-1;
Gene ID : 240354
mRNA Refseq : NM_172833
Protein Refseq : NP_766421
UniProt ID : Q2TBA3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MALT1 protein play a role in regulating immune responses in transplant patients? 07/21/2022

MALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.

Are there any genetic mutations or polymorphisms related to MALT1 protein that impact patient health? 04/03/2022

Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.

Are there any clinical applications for MALT1 protein in cancer research? 12/21/2020

Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.

Can MALT1 protein be targeted for cancer treatment? 02/02/2018

Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.

How does MALT1 protein contribute to lymphocyte activation and proliferation? 03/19/2016

MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.

Customer Reviews (3)

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Reviews
06/26/2022

    From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.

    08/19/2020

      the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

      03/20/2020

        the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

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