mrps22
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  • Official Full Name
  • mitochondrial ribosomal protein S22
  • Background
  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.
  • Synonyms
  • MRPS22; mitochondrial ribosomal protein S22; 28S ribosomal protein S22, mitochondrial; C3orf5; GIBT; GK002; MRP S22; COXPD5; RPM S22; RPMS22; S22mt; MRP-S22
Cat.#:MRPS22-5610HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MRPS22 Protein, GST-tagged
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Cat.#:MRPS22-10094MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MRPS22 Protein
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Cat.#:MRPS22-5699ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MRPS22
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Cat.#:MRPS22-4144HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MRPS22 293 Cell Lysate
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Involved Pathway

MRPS22 involved in several pathways and played different roles in them. We selected most pathways MRPS22 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPS22 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mitochondrial translation
GADD45GIP1; MRPL28; MRPL55; TUFM; MRPL3; MRPS34; GFM2; MTRF1L; MRPS27; MRPS33
Mitochondrial translation elongation
MRPS27; MRPL28; MRPS23; CHCHD1; MRPL52; MRPS25; MRPL53; MRPS33; TUFM; MRPL49
Mitochondrial translation initiation
MTFMT; MRPS34; MRPL40; MRPL53; MRPS23; MRPL51; MRPL37; GADD45GIP1; MRPS36; ICT1
Mitochondrial translation termination
MRPS26; GFM2; MRPL49; MRPS33; MRPL40; CHCHD1; MRPL42; MRRF; MRPS31; MRPL45
Organelle biogenesis and maintenance
ARF4; MRPL45; RPGRIP1L; MRPL50; MRPL40; MRPS22; AURKAIP1; IFT27; EXOC8; TUFM

Protein Function

MRPS22 has several biochemical functions, for example, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPS22 itself. We selected most functions MRPS22 had, and list some proteins which have the same functions with MRPS22. You can find most of the proteins on our site.
Function
Related Protein
Function structural constituent of ribosome
Related Protein RPL32; RPS8A; MRPS18C; RPS17; RPS3A; MRPL9; MRPL23; MRPL41; MRPS7; RPL5B

Interacting Protein

MRPS22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPS22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPS22.
C1qbp; ESR2; Ybx1; NFKBIL1; BTK; SHD; Smad6; MYC; ESR1; TP53; ERBB3; YBX1; ICT1; MAP1LC3A; AGO2; AGO1; SIRT4

MRPS22 Related Articles

Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).