nek2
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  • Official Full Name
  • NIMA (never in mitosis gene a)-related kinase 2
  • Background
  • NEK2 is a serine/threonine kinase involved in mitotic regulation. NEK2 also known as serine/threonine protein kinase Nek2, NimA-related protein kinase 2, and HSPK21, can be expressed as 3 different isoforms as a result of alternative splicing.. The predic
  • Synonyms
  • NEK2; NIMA (never in mitosis gene a)-related kinase 2; serine/threonine-protein kinase Nek2; HsPK 21; NEK2A; NLK1; nimA-like protein kinase 1; nimA-related protein kinase 2; HsPK21
Cat.#:NEK2-788HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK2 Protein, His-tagged
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Cat.#:Nek2-789MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nek2 Protein, His-tagged
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Cat.#:Nek2-790RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nek2 Protein, His-tagged
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Cat.#:NEK2-1258HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK2, GST-tagged
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Cat.#:NEK2-29279THTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK2
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Cat.#:NEK2-549HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human NEK2, GST-tagged
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Cat.#:NEK2-10572MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NEK2 Protein
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Cat.#:NEK2-2998RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NEK2 Protein, His-tagged
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Cat.#:NEK2-2730CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEK2
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Cat.#:NEK2-11278ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NEK2
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Cat.#:NEK2-368HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK2, GST-tagged, Active
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Cat.#:NEK2-558HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK2, His-tagged
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Cat.#:NEK2-663HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK2, Active
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Cat.#:NEK2-1183HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK2 cell lysate
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Involved Pathway

NEK2 involved in several pathways and played different roles in them. We selected most pathways NEK2 participated on our site, such as APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC-Cdc20 mediated degradation of Nek2A
NEK2; ANAPC10; UBE2C
APC/C-mediated degradation of cell cycle proteins
AURKB; NEK2; PSMD10; PSMD5; PSMA8; ANAPC10; PSME3; UBE2C; PSMD9; PSMD14
APC/C:Cdc20 mediated degradation of mitotic proteins
PSMD10; ANAPC10; PSMA8; PSME3; PSMD9; PSMD5; NEK2; UBE2C; PSMD14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PSMD9; PSMD5; UBE2C; PSMD14; PSME3; PSMA8; NEK2; ANAPC10; PSMD10
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
PSMD5; UBE2C; PSMD14; PSMA8; NEK2; PSMD9; ANAPC10; PSME3; PSMD10
Anchoring of the basal body to the plasma membrane
CEP89; DCTN2; AKAP9; DCTN1A; CEP290; FBF1; CEP78; CCP110; TCTN3; RPGRIP1L
Assembly of the primary cilium
MKS1; BBS2; KIF3CB; KIFAP3B; CENPJ; IFT20; RAB3IP; DYNLL2A; FLR; TCP1
Cell Cycle
RAD9A; NSL1; MCM4; ODF2B; OIP5; AHCTF1; CCNA1; ANAPC5; YWHAB; CEP152

Protein Function

NEK2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK2 itself. We selected most functions NEK2 had, and list some proteins which have the same functions with NEK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKDCCA; ABCG2B; FARS2; UBE2E2; DNAJA4; TEP1; TP53; RAD51D; MAT2AL; LIG3
Function metal ion binding
Related Protein GTF3A; CYP2AA1; FRAS1; MUSK; ATP5S; ATP13A5; GNA15; NUAK1; STS; AGAP2
Function protein binding
Related Protein MED12; Ctsl; CENPL; SERPINA5; SCMH1; SNX11; COL17A1; CPSF2; RAET1D; OAS1A
Function protein kinase activity
Related Protein LTK; MINK1; SNRKA; CDKL2; CCND1; DYRK1B; NPR1; PKN1; EPHB2B; PKN1B
Function protein phosphatase binding
Related Protein ANAPC4; PIK3R2; CSK; KAT2A; ROS1; CSF1R; CDKN1B; RPA2; CDH2; PPP1R3C
Function protein serine/threonine kinase activity
Related Protein PRKD1; TTBK2; MYO3B; STK31; MINK1; AKT2; MAP4K4; CDK15; ULK3; BRAF

Interacting Protein

NEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK2.
NEK11; Cdc23; Cdc16; Cdc26; CDC16; cdc27; CDC27

NEK2 Related Articles

Mbom, BC; Siemers, KA; et al. Nek2 phosphorylates and stabilizes beta-catenin at mitotic centrosomes downstream of Plk1. MOLECULAR BIOLOGY OF THE CELL 25:977-991(2014).
Kim, S; Hwang, SK; et al. Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45:1953-1961(2013).