padi2
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  • Official Full Name
  • peptidyl arginine deiminase, type II
  • Background
  • This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
  • Synonyms
  • PADI2; peptidyl arginine deiminase, type II; protein-arginine deiminase type-2; KIAA0994; PDI2; OTTHUMP00000044625; PAD 2; PAD H19; PADI 2; PADI2 protein; PDI 2; Peptidlyarginine deiminase type II; Peptidyl arginine deiminase II; Peptidyl arginine deiminase type II; Peptidylarginine deiminase II; Protein arginine deiminase; Protein arginine deiminase type 2; Protein arginine deiminase type II; OTTHUMP00000002403; OTTHUMP00000002404; protein-arginine deiminase type II; PAD2; PAD-H19
Cat.#:PADI2-1164HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PADI2 Protein (1-665 aa), His-SUMO-tagged
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Cat.#:PADI2-311HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PADI2 Protein, His/GST-tagged
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Cat.#:PADI2-186HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PADI2, GST-tagged
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Cat.#:PADI2-187HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PADI2, Flag-tagged
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Cat.#:PADI2-5628HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PADI2, MYC/DDK-tagged
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Cat.#:Padi2-1606Tag:GST
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Padi2 protein, GST-tagged
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Cat.#:Padi2-1606MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Padi2, GST-tagged
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Cat.#:PADI2-6979MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse PAD2, GST-tagged
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Cat.#:PADI2-4249RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PADI2 Protein
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Cat.#:PADI2-3281RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PADI2 Protein, His-tagged
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Cat.#:PADI2-10464ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PADI2
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Involved Pathway

PADI2 involved in several pathways and played different roles in them. We selected most pathways PADI2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
HIST2H3C; NCOA2; SMARCB1; KAT6B; KAT5; KDM3A; PADI4; MORF4L1; SUZ12B; KDM1A
Chromatin organization
MORF4L1; ING5; SMYD3; KIAA1267; KDM2AA; KDM5B; RBBP7; SMYD2; KAT6B; SMARCB1B
protein citrullination
PADI4; PADI2; PADI6; PADI3; PADI1

Protein Function

PADI2 has several biochemical functions, for example, calcium ion binding, estrogen receptor binding, protein-arginine deiminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI2 itself. We selected most functions PADI2 had, and list some proteins which have the same functions with PADI2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein NINL; LRP2A; DSG2.1; TC2N; RPH3A; EFCAB5; CABP1B; IHH; RCN3; CAPN2
Function estrogen receptor binding
Related Protein MMS19; LEF1; CCDC62; PPARG; DDX5; WIPI1; NCOA1; TAF10; FOXL2; TRIP4
Function protein-arginine deiminase activity
Related Protein PADI6; PADI1; PADI3; PADI2; PADI4

Interacting Protein

PADI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI2.
MYC

PADI2 Related Articles

Hsu, PC; Liao, YF; et al. Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells. MOLECULES AND CELLS 37:426-434(2014).
Chang, XT; Xia, YF; et al. PADI2 Is Significantly Associated with Rheumatoid Arthritis. PLOS ONE 8:-(2013).