Active Recombinant Human PADI2 Protein, His-tagged

• Cat.No.: PADI2-102H
• Product Overview: Active recombinant N-terminal His-tagged human PADI2 protein was isolated from a baculovirus overexpression system.

Specification

• Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
• Source: Insect cell
• Species: Human
• Tag: His
• Bio-activity: ≥500 U/mg
• Molecular Mass: 77.32 kDa
• Purity: ≥90% as determined by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 nmol of NH4+ per minute at 37 centigrade in 50 mM HEPES, pH 7.7, containing 10 mM calcium chloride, 5 mM DTT, and 5 mM N-α-Benzoyl-L-Arginineethylester(BAEE).
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM HEPES, pH 8.0, with 200 mM NaCl, 1 mM DTT and 10% glycerol

Gene Information

• Gene Name: PADI2 peptidyl arginine deiminase 2 [ Homo sapiens (human) ]
• Official Symbol: PADI2
• Synonyms: PADI2; peptidyl arginine deiminase 2; PAD2; PDI2; PAD-H19; protein-arginine deiminase type-2; peptidyl arginine deiminase, type II; protein-arginine deiminase type II; EC 3.5.3.15
• Gene ID: 11240
• mRNA Refseq: NM_007365
• Protein Refseq: NP_031391
• MIM: 607935
• UniProt ID: Q9Y2J8