pde10a
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  • Official Full Name
  • PDE10A phosphodiesterase 10A
  • Background
  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal;transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP;and cGMP to the corresponding nucleoside 5 monophosphate, but has higher affinity for cAMP, and is more efficient;with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
  • Synonyms
  • PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677
Cat.#:PDE10A-304HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDE10A Protein, His-tagged
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Cat.#:PDE10A-1610Tag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PDE10A protein, GST-tagged
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Cat.#:PDE10A-1610HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE10A, GST-tagged
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Cat.#:PDE10A-440HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphodiesterase 10A, GST-tagged
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Cat.#:PDE10A-12544MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDE10A Protein
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Cat.#:Pde10a-438MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Phosphodiesterase 10A, GST-tagged
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Cat.#:PDE10A-4324RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE10A Protein
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Cat.#:Pde10a-439RTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Rat
Product nameRecombinant Rat Phosphodiesterase 10A, GST-tagged
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Cat.#:PDE10A-11324ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDE10A
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Cat.#:PDE10A-3355HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE10A 293 Cell Lysate
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Cat.#:Kit-2043Tag:
Source (Host):Species:
Product namePDE10A Assay Kit
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Involved Pathway

Pde10a involved in several pathways and played different roles in them. We selected most pathways Pde10a participated on our site, such as G alpha (s) signalling events, GPCR downstream signaling, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pde10a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
G alpha (s) signalling events
ADCYAP1R1; PTH2; TAAR1; PTH; RLN2; PDE10A; ADM2A; INSL3; CRHR1; CALCRL
GPCR downstream signaling
CRHR1; ANXA1C; EDNRB; DGKQ; RGS14; PTGDR2; RGS17; RLN3A; ECT2; NPFFR2
Hemostasis
G6b; HBBE3; MMRN1; SLC8A2A; DOCK8; IRF1B; AASS; SLC7A8A; ANXA2; KIF3B
Morphine addiction
GABRD; PDE7A; OPRM1; ADORA1; GNAS; GNAI2; PDE11A; PDE10A; GABRQ; PRKCG
Nitric oxide stimulates guanylate cyclase
KCNMB2; PDE10A; KCNMB1; KCNMA1
Platelet homeostasis
SLC8A2A; ATP2B3A; APOER2; KCNMB2; PDE10A; KCNMB1; KCNMA1; ATP2B1B
Purine metabolism
PAICS; NME1-NME2; PDE6C; PAPSS2B; GUCY2F; RRM2; NT5C2; PDE4B; NT5C1BA; XDH
Signal Transduction
TAC2; DLK1; SOX9B; SOUL4; ADM2; TAX1BP1; KIDINS220B; SH2B3; OR4D2; TAS2R13

Protein Function

Pde10a has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pde10a itself. We selected most functions Pde10a had, and list some proteins which have the same functions with Pde10a. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-GMP phosphodiesterase activity
Related Protein PDE5A; PDE6B; PDE10A; PDE6G; PDE6C; PDE6A; PDE11A; PDE9A; PDE6H
Function 3,5-cyclic-nucleotide phosphodiesterase activity
Related Protein PDE8B; PDE5A; PDE9A; PDE6D; PDE10A; PDE8A; PDE4D; PDE5AB; PDE3B; PDE11A
Function cAMP binding
Related Protein CNGA2; PRKAR2B; PRKAR2A; PDE4B; PDE4A; PRKAR1A; RAPGEF4; CNMPD1; HCN2; PDE2A
Function cGMP binding
Related Protein PRKG2; PRKG1A; PDE6C; CNGA1; CNGA4; PRKG1; PDE11A; PDE6H; PDE2A; PDE10A
Function cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Related Protein TDP2B; PDE11A; PDE10A; USB1; PDE2A
Function drug binding
Related Protein SLC6A4A; HTR2A; GABRA1; RARB; PDE10A; FOLR2; HMGCS1; GSTP2; PPARD; MT2A
Function metal ion binding
Related Protein GIT2B; ZFP629; AGBL4; TGM2; ALDH1A2; COX4I2; ZNF26; PAPL; PRDM1; GALNT12

Interacting Protein

Pde10a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pde10a here. Most of them are supplied by our site. Hope this information will be useful for your research of Pde10a.
WDR3

Pde10a Related Articles

Guez-Barber, D; Fanous, S; et al. FACS purification of immunolabeled cell types from adult rat brain. JOURNAL OF NEUROSCIENCE METHODS 203:10-18(2012).
Charych, EI; Jiang, LX; et al. Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia. JOURNAL OF NEUROSCIENCE 30:9027-9037(2010).