|Product Overview :||Recombinant Human PDE10A(Asn508~Asp779) fused with His tag at N-terminal was expressed in E. coli.|
|Description :||The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.|
|Source :||E. coli|
|Form :||20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.|
|Molecular Mass :||34.7kDa|
|Protein length :||Asn508~Asp779|
|Endotoxin :||<1.0EU per 1µg (determined by the LAL method)|
|Purity :||> 95%|
|Applications :||Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.|
|Reconstitution :||Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
|Gene Name :||PDE10A phosphodiesterase 10A [ Homo sapiens ]|
|Official Symbol :||PDE10A|
|Synonyms :||PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677;|
|Gene ID :||10846|
|mRNA Refseq :||NM_001130690|
|Protein Refseq :||NP_001124162|
|UniProt ID :||Q9Y233|