ptgdr2
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  • Official Full Name
  • prostaglandin D2 receptor 2
  • Background
  • This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3 UTR of this gene have been associated with asthma susceptibility.
  • Synonyms
  • PTGDR2; prostaglandin D2 receptor 2; G protein coupled receptor 44 , GPR44; putative G-protein coupled receptor 44; CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; CRTH2; DP2; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; DL1R; G Protein Coupled Receptor 44; GPR 44; Gpr44; GPR44_HUMAN; Putative G protein coupled receptor 44; G protein-coupled receptor 44
Cat.#:PTGDR2-4803RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGDR2 Protein
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Cat.#:CSC-RG0465Tag:
Source (Host):Species:Human
Product nameHuman PTGDR2-FLAG Stable Cell Line-HEK293T
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Cat.#:CSC-RG0496Tag:
Source (Host):Species:Human
Product nameHuman PTGDR2/Gi Stable Cell Line-CHO
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Cat.#:CSC-RG0586Tag:
Source (Host):Species:Human
Product nameHuman PTGDR2-FLAG Stable Cell Line-HEK293T
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Involved Pathway

PTGDR2 involved in several pathways and played different roles in them. We selected most pathways PTGDR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDR2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
MLN; UTS2D; HRH3; CYSLTR1; ACKR4; GPR4; NMS; NMBA; GPR65; TAAR1
Eicosanoid ligand-binding receptors
LTB4R; CYSLTR1; OXER1; PTGDR2; GPR17
G alpha (i) signalling events
S1PR1; ADRA2C; NPB; OXGR1A.2; POMCB; PNOCB; PENKB; RGS19; LPAR2A; ANXA1A
GPCR downstream signaling
RGS4; S1PR5B; ARHGEF3; GPR132; ARHGEF18; ADORA1; AMCF-II; ARHGEF1A; HCAR1-2; PLEKHG2
GPCR ligand binding
EDNRB; ADORA3; GPR37B; ADCYAP1R1; AGTR2; ADM2A; AGT; CRH; GPR132; ADCYAP1B
GPCRs, Class A Rhodopsin-like
SSTR1; FFAR3; DRD4; GPR65; OPN1SW; OPN1LW; APLNR; CCR7; GPR4; CCR3
Prostanoid ligand receptors
PTGDR2
Signal Transduction
CSN2; KISS1; WDR35; ADM2A; TAX1BP3; RSPO3; RDH14; TLE3B; ABCA4A; SOX7

Protein Function

PTGDR2 has several biochemical functions, for example, G-protein coupled receptor activity, neuropeptide binding, prostaglandin D receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDR2 itself. We selected most functions PTGDR2 had, and list some proteins which have the same functions with PTGDR2. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein GPRC5C; DARC; V2RX1; OXGR1; TAS2R126; TMTOPS3A; GNRHR1; TMTOPS3B; ADRA1BB; GRM8B
Function neuropeptide binding
Related Protein OPRD1A; SSTR5; OPRD1; SSTR2; GALR1; MC3R; NPBWR1; GPR149; OPRD1B; ADCYAP1R1
Function prostaglandin D receptor activity
Related Protein PTGDR2; PTGDR
Function prostaglandin F receptor activity
Related Protein PTGDR2; PTGFR; PTGER1C
Function prostaglandin J receptor activity
Related Protein PTGDR2; PTGDR