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SOX8

  • Official Full Name

    SRY (sex determining region Y)-box 8

  • Overview

    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
  • Synonyms

    SOX8; SRY (sex determining region Y)-box 8; transcription factor SOX-8; MGC24837; SOX 8; SRY (sex determining region Y) box 8; SRY box 8; SRY box containing gene 8; Transcription factor SOX 8; Transcription factor SOX8; OTTHUMP00000151195;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOX8-2885H Recombinant Human SOX8, His-tagged E.coli His C-149aa
Human SOX8-1673M Sol8 (mouse myoblast) whole cell lysate N/A
Human SOX8-1743H Recombinant Human SOX8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOX8-2419H Recombinant Human SOX8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse SOX8-15787M Recombinant Mouse SOX8 Protein Mammalian Cell His
Mouse SOX8-8594M Recombinant Mouse SOX8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sox8-6059M Recombinant Mouse Sox8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SOX8-8594M-B Recombinant Mouse SOX8 Protein Pre-coupled Magnetic Beads HEK293
Chicken SOX8-6296C Recombinant Chicken SOX8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SOX8 involved in several pathways and played different roles in them. We selected most pathways SOX8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SOX8 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX8 itself. We selected most functions SOX8 had, and list some proteins which have the same functions with SOX8. You can find most of the proteins on our site.

Function Related Protein
DNA bindingFUS;POLN;HOXC11A;EGR2B;EPAS1B;TSN;LHX8A;ISL2A;ZNF547
RNA polymerase II core promoter sequence-specific DNA bindingMITF;MAZ;GATA1;NR4A2;WBP2;GBX2;IRF7;SPI1;TFAP2B
RNA polymerase II transcription factor activity, sequence-specific DNA bindingSOX5;MITFA;RUNX2B;FOXQ1A;ETV4;ELF2B;FOXK1;JUND;SIM1A
protein heterodimerization activityIKBKG;HIST1H3G;TCF3;TLR6;GUCY1A3;SYCP2;CHUK;ZBTB1;TFDP3
transcription factor bindingEP300;PPP1R13L;TAF12;TNFRSF10A;NFATC2;CTBP1;SOX8;CRY1;PIAS2

SOX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX8.

MMP1; JAM2; PIDD1; NOD1

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