tfam
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  • Official Full Name
  • transcription factor A, mitochondrial
  • Background
  • This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimers and Parkinsons diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
  • Synonyms
  • TFAM; transcription factor A, mitochondrial; TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor);
Cat.#:TFAM-654HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFAM Protein, His/GST-tagged
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Cat.#:Tfam-655MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tfam Protein, His/GST-tagged
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Cat.#:Tfam-656RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tfam Protein, His/GST-tagged
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Cat.#:TFAM-3416HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFAM, His-tagged
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Cat.#:TFAM-1579HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human TFAM protein
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Cat.#:TFAM-30255THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFAM, His-tagged
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Cat.#:TFAM-16675MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TFAM Protein
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Cat.#:Tfam-27MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tfam protein, His/GST-tagged
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Cat.#:TFAM-6024RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TFAM Protein
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Cat.#:TFAM-5676CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TFAM
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Cat.#:TFAM-4721ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TFAM
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Cat.#:TFAM-1765HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TFAM cell lysate
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Involved Pathway

TFAM involved in several pathways and played different roles in them. We selected most pathways TFAM participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Huntingtons disease
PLCB4; NRF1; DNAL4; GPX1; CREB3L3; POLR2J3; COX7A1; EP300; NDUFA6; POLR2J2

Protein Function

TFAM has several biochemical functions, for example, DNA binding, bending, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAM itself. We selected most functions TFAM had, and list some proteins which have the same functions with TFAM. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding, bending
Related Protein HMGA2; HMGB1; SRY; HHEX; FOXL1; CRIP1; LEF1; HMGB2; GATA1; FOXD4
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TFAP4; ZNF253; MITF; BATF; EN1; MYC; BCL11A; MAFB; FOXL2; CTCFL
Function chromatin binding
Related Protein APITD1; ATAD2B; SOD3; HMGN5; NCOA2; EED; COQ7; JDP2; KAT2B; HOXC13
Function heat shock protein binding
Related Protein DMPK; GM5506; TFAM; DNAJA2; KCNJ11; HSPA9; PPP5C; DNAJA3; DNAJA2L; DAXX
Function mitochondrial light strand promoter sense binding
Related Protein TFAM
Function poly(A) RNA binding
Related Protein AGO3; CEBPZ; DHX15; AKAP17A; RBM7; TRNAU1AP; DDX5; KHDRBS3; ZNFX1; ASS1
Function protein binding
Related Protein PDZK1; PTPN7; MBIP; HCK; SETMAR; CCDC148; STAT6; DTNBP1; TAF3; TM4SF4
Function transcription factor activity, sequence-specific DNA binding
Related Protein L3MBTL1; EGR4; ARNTL2; TFAP2C; HOXB5A; MECP2; BTBD8; HMGA1; TBX22; ATF6B
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HOXD13; HOXA5; BATF; TP63; GATA2; POU3F2; MAFA; NR4A1; TFAP2A; EBF4

Interacting Protein

TFAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAM here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAM.
ARL6IP1; AGTRAP; TFB1M; C1qbp; TFB2M; MCC; IKBKE; TNIK; ssrna_cg

TFAM Related Articles

Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
Vadrot, N; Ghanem, S; et al. Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3 beta and p53 in Response to Tumor Necrosis Factor alpha. PLOS ONE 7:-(2012).